Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice.
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Local amplification of glucocorticoids in the aging brain and impaired spatial memoryPharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid DehydrogenasesFuture technology insight: mass spectrometry imaging as a tool in drug research and development.Stress response and child health.Mass spectrometry imaging for dissecting steroid intracrinology within target tissues11β-Hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men.11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.Aging and stress: past hypotheses, present approaches and perspectivesCognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease.Prenatal arsenic exposure alters the programming of the glucocorticoid signaling system during embryonic development.Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects.Prenatal alcohol exposure is associated with altered subcellular distribution of glucocorticoid and mineralocorticoid receptors in the adolescent mouse hippocampal formation.Vitamin A status regulates glucocorticoid availability in Wistar rats: consequences on cognitive functions and hippocampal neurogenesis?Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery.11β-HSD1 inhibitors for the treatment of type 2 diabetes and cardiovascular disease.Tissue-specific dysregulation of cortisol regeneration by 11βHSD1 in obesity: has it promised too much?Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged micePhospholipid transfer protein (PLTP) deficiency accelerates memory dysfunction through altering amyloid precursor protein (APP) processing in a mouse model of Alzheimer's disease.Diurnal and stress-induced intra-hippocampal corticosterone rise attenuated in 11β-HSD1-deficient mice: a microdialysis study in young and aged miceDecreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice.Selective inhibition of phosphodiesterase 5 enhances glutamatergic synaptic plasticity and memory in mice.Amphetamine withdrawal differentially affects hippocampal and peripheral corticosterone levels in response to stress.11beta-hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive controlIntrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice.Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice.11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.Midlife stress alters memory and mood-related behaviors in old age: Role of locally activated glucocorticoids.Cognition in aged rhesus monkeys: effect of DHEA and correlation with steroidogenic gene expression.Translational Research in Stress Neuroendocrinology: 11β-Hydroxysteroid Dehydrogenase 1 (11β-HSD1), A Case Study
P2860
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P2860
Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Partial deficiency or short-te ...... nitive function in aging mice.
@en
type
label
Partial deficiency or short-te ...... nitive function in aging mice.
@en
prefLabel
Partial deficiency or short-te ...... nitive function in aging mice.
@en
P2093
P2860
P1476
Partial deficiency or short-te ...... gnitive function in aging mice
@en
P2093
Brian R Walker
Jonathan R Seckl
Joyce L W Yau
June Noble
Karen Sooy
Margaret Binnie
P2860
P304
13867-13872
P356
10.1523/JNEUROSCI.2783-10.2010
P407
P577
2010-10-01T00:00:00Z