Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. - Wikidata - awgldk - TriplyDB

Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.

Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.

http://www.wikidata.org/entity/Q30495284

about

Cortical dynein is critical for proper spindle positioning in human cells MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis The G protein α chaperone Ric-8 as a potential therapeutic target Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad RGS14 at the interface of hippocampal signaling and synaptic plasticity Human Nek7-interactor RGS2 is required for mitotic spindle organization.B Lymphocyte-Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency.Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions DNA Damage Response Checkpoint Activation Drives KP1019 Dependent Pre-Anaphase Cell Cycle Delay in S. cerevisiae Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A NCAM180 regulates Ric8A membrane localization and potentiates β-adrenergic response NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation.Ric-8: different cellular roles for a heterotrimeric G-protein GEF.Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.Canonical and noncanonical g-protein signaling helps coordinate actin dynamics to promote macrophage phagocytosis of zymosan SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation Loss of Gαi proteins impairs thymocyte development, disrupts T-cell trafficking, and leads to an expanded population of splenic CD4+PD-1+CXCR5+/- T-cells Implications of non-canonical G-protein signaling for the immune system The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.Asymmetric cell divisions promote Notch-dependent epidermal differentiation.A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cells Overexpression of the dynein light chain km23-1 in human ovarian carcinoma cells inhibits tumor formation in vivo and causes mitotic delay at prometaphase/metaphase.Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization.G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis.Cell shape impacts on the positioning of the mitotic spindle with respect to the substratum.Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning.Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis.Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation.Cell cycle-regulated cortical dynein/dynactin promotes symmetric cell division by differential pole motion in anaphase.

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Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.

http://www.wikidata.org/entity/Q30495284

description

2010 nî lūn-bûn

@nan

2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.

@ast

Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.

@en

type

label

Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.

@ast

Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.

@en

prefLabel

Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.

@ast

Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.

@en

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Molecular and Cellular Biology

P1476

Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.

@en

P2093

Geoffrey E Woodard

http://www.w3.org/2001/XMLSchema#string

Gregory G Tall

http://www.w3.org/2001/XMLSchema#string

Hyeseon Cho

http://www.w3.org/2001/XMLSchema#string

John H Kehrl

http://www.w3.org/2001/XMLSchema#string

Ning-Na Huang

http://www.w3.org/2001/XMLSchema#string

Toru Miki

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins

Galphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts

A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration.

Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization

New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart

Experimental and theoretical study of mitotic spindle orientation

Chromosomal passengers: conducting cell division

Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner.

Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts.

P304

3519-3530

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scholarly article

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10.1128/MCB.00394-10

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14

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30

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2010-05-17T00:00:00Z

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20479129

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2897540

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