BACE1 deficiency causes altered neuronal activity and neurodegeneration. - Wikidata - awgldk - TriplyDB

BACE1 deficiency causes altered neuronal activity and neurodegeneration.

BACE1 deficiency causes altered neuronal activity and neurodegeneration.

http://www.wikidata.org/entity/Q30495458

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Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs Diverse impact of acute and long-term extracellular proteolytic activity on plasticity of neuronal excitability The normal and pathologic roles of the Alzheimer's β-secretase, BACE1 BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 BACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortex Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease APP knockout mice experience acute mortality as the result of ischemia.Targeting the β secretase BACE1 for Alzheimer's disease therapy.Reduced sodium channel Na(v)1.1 levels in BACE1-null mice APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner.Drug development for Alzheimer's disease: recent progress VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb.BACE2 expression increases in human neurodegenerative disease.MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons The keystone of Alzheimer pathogenesis might be sought in Aβ physiology The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo "Untangling" Alzheimer's disease and epilepsy.β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice.Association of BACE1 Gene Polymorphism with Cerebellar Volume but Not Cognitive Function in Normal Individuals.Cellular and animal models for high-throughput screening of therapeutic agents for the treatment of the diseases of the elderly in general and Alzheimer's disease in particular(†).BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.β-Secretase: its biology as a therapeutic target in diseases Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway.Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.High activities of BACE1 in brains with mild cognitive impairment.BACE1 activity regulates cell surface contactin-2 levels.Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms.β-secretase cleavage of the fly amyloid precursor protein is required for glial survival Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.

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BACE1 deficiency causes altered neuronal activity and neurodegeneration.

http://www.wikidata.org/entity/Q30495458

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

BACE1 deficiency causes altered neuronal activity and neurodegeneration.

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BACE1 deficiency causes altered neuronal activity and neurodegeneration.

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type

label

BACE1 deficiency causes altered neuronal activity and neurodegeneration.

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BACE1 deficiency causes altered neuronal activity and neurodegeneration.

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prefLabel

BACE1 deficiency causes altered neuronal activity and neurodegeneration.

@ast

BACE1 deficiency causes altered neuronal activity and neurodegeneration.

@en

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JNEUROSCI.1334-10.2010

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Journal of Neuroscience

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BACE1 deficiency causes altered neuronal activity and neurodegeneration.

@en

P2093

Christopher G Wilson

http://www.w3.org/2001/XMLSchema#string

Jun Yang

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Philip Wong

http://www.w3.org/2001/XMLSchema#string

Riqiang Yan

http://www.w3.org/2001/XMLSchema#string

Wanxia He

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Wencheng Xiong

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Xiangdong Zhou

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Xiangyou Hu

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

BACE (beta-secretase) modulates the processing of APLP2 in vivo

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

Sodium-channel defects in benign familial neonatal-infantile seizures

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

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10.1523/JNEUROSCI.1334-10.2010

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44888962

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20592204

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