BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. - Wikidata - awgldk - TriplyDB

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

http://www.wikidata.org/entity/Q35945545

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Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined Lysophospholipids and their receptors in the central nervous system Fingolimod for the treatment of neurological diseases-state of play and future perspectives BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system Network Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer's Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the Disease Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.Effect of alkyl chain length on sphingosine kinase 2 selectivity.Cross-talk of membrane lipids and Alzheimer-related proteins.Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.Development of small-molecule inhibitors of sphingosine-1-phosphate signaling Sphingosine-1-phosphate signaling and its role in disease.The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain.Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer's disease?β-Secretase: its biology as a therapeutic target in diseases Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis.Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease.APP Function and Lipids: A Bidirectional Link.Roles of sphingosine-1-phosphate in reproduction.The role of sphingolipid signalling in diabetes‑associated pathologies (Review).The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity.Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease.Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells.Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.Targeting sphingosine-1-phosphate signaling in lung diseases.Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase.Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells.Crosstalk between sphingolipids and vitamin D3: potential role in the nervous system.Metabolomic-guided discovery of Alzheimer's disease biomarkers from body fluid.Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.Targeting sphingosine-1-phosphate signaling for cancer therapy.

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BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

http://www.wikidata.org/entity/Q35945545

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2011 nî lūn-bûn

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2011年论文

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2011年论文

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name

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

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BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

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type

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BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

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BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

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prefLabel

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

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BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

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JNEUROSCI.6467-10.2011

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Journal of Neuroscience

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BACE1 activity is modulated by cell-associated sphingosine-1-phosphate

@en

P2093

Hayato Isshiki

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John Q Trojanowski

http://www.w3.org/2001/XMLSchema#string

Kunimichi Suzuki

http://www.w3.org/2001/XMLSchema#string

Naoaki Shimada

http://www.w3.org/2001/XMLSchema#string

Nobumasa Takasugi

http://www.w3.org/2001/XMLSchema#string

Satoko Osawa

http://www.w3.org/2001/XMLSchema#string

Takeshi Iwatsubo

http://www.w3.org/2001/XMLSchema#string

Takuya Higo

http://www.w3.org/2001/XMLSchema#string

Tohru Fukuyama

http://www.w3.org/2001/XMLSchema#string

Tomoki Sasaki

http://www.w3.org/2001/XMLSchema#string

P2860

CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV

Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

Control of peripheral nerve myelination by the beta-secretase BACE1

Essential role for sphingosine kinases in neural and vascular development

IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses

Modeling an anti-amyloid combination therapy for Alzheimer's disease.

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

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6850-6857

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scholarly article

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10.1523/JNEUROSCI.6467-10.2011

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18

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31

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Satoshi Yokoshima

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2011-05-01T00:00:00Z

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21543615

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4534000

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