Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo - Wikidata - awgldk - TriplyDB

Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo

Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo

http://www.wikidata.org/entity/Q30497635

about

Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?The osteocyte as a therapeutic target in the treatment of osteoporosis Potential role for therapies targeting DKK1, LRP5, and serotonin in the treatment of osteoporosis Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner Effects of androgen deprivation therapy and bisphosphonate treatment on bone in patients with metastatic castration-resistant prostate cancer: results from the University of Washington Rapid Autopsy Series Gremlin1 is required for skeletal development and postnatal skeletal homeostasis Wnt signaling and orthopedics, an overview High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.Targeting Wnt pathways in disease.Immunogenetic study in Chinese population with ankylosing spondylitis: are there specific genes recently disclosed?Wnt signaling in bone formation and its therapeutic potential for bone diseases.Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy.LRP5 and bone mass regulation: Where are we now?Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction Estrogen regulation of Dkk1 and Wnt/β-Catenin signaling in neurodegenerative disease.An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity.Wnt proteins in mineralized tissue development and homeostasis.Osteoblastogenesis regulation signals in bone remodeling.Systemic effects of Wnt signaling.Fat and bone interactions.Biological agents in management of osteoporosis.Osteocytic signalling pathways as therapeutic targets for bone fragility.New Target Sites for Treatment of Osteoporosis.Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model.Osteoblast as a target of anti-osteoporotic treatment.Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation.Vaccination with DKK1-derived peptides promotes bone formation and bone mass in an aged mouse osteoporosis model.Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.Effects of iguratimod on the levels of circulating regulators of bone remodeling and bone remodeling markers in patients with rheumatoid arthritis.

P2860

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P2860

Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo

http://www.wikidata.org/entity/Q30497635

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Generation and selection of no ...... and increase bone mass in vivo

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Generation and selection of no ...... and increase bone mass in vivo

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type

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Generation and selection of no ...... and increase bone mass in vivo

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Generation and selection of no ...... and increase bone mass in vivo

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Generation and selection of no ...... and increase bone mass in vivo

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Generation and selection of no ...... and increase bone mass in vivo

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P1433

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P356

JBC.M110.166892

P1433

Journal of Biological Chemistry

P1476

Generation and selection of no ...... and increase bone mass in vivo

@en

P2093

Alfred A Reszka

http://www.w3.org/2001/XMLSchema#string

Cheryl Ireland

http://www.w3.org/2001/XMLSchema#string

Donald Kimmel

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Fabio Talamo

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Fubao Wang

http://www.w3.org/2001/XMLSchema#string

Helmut Glantschnig

http://www.w3.org/2001/XMLSchema#string

Jing Z Zhao

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John E Fisher

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Kevin R Scott

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Laura Orsatti

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P2860

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins.

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Colipase: structure and interaction with pancreatic lipase

High bone mass in mice expressing a mutant LRP5 gene

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40135-40147

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scholarly article

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10.1074/JBC.M110.166892

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P407

P433

51

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P478

285

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P577

2010-10-07T00:00:00Z

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20929859

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3000996

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