RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins - Wikidata - awgldk - TriplyDB

RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins

RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins

http://www.wikidata.org/entity/Q30498021

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Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells Targeting the neddylation pathway to suppress the growth of prostate cancer cells: therapeutic implication for the men's cancer.Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.Screening of UV-B-induced genes from apple peels by SSH: possible involvement of MdCOP1-mediated signaling cascade genes in anthocyanin accumulation.Knockdown of regulator of cullins-1 (ROC1) expression induces bladder cancer cell cycle arrest at the G2 phase and senescence.SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.Characterization of SCF-Complex during Bovine Preimplantation Development CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapy Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway.Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells.Molecular targets and mechanisms of radiosensitization using DNA damage response pathways.Suppression of tumor angiogenesis by targeting the protein neddylation pathway.Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases.Cullin-RING Ligases as attractive anti-cancer targets.MLN4924 therapy as a novel approach in cancer treatment modalities.Biological determinants of radioresistance and their remediation in pancreatic cancer.Ubiquitin Ligases and Posttranslational Regulation of Energy in the Heart: The Hand that Feeds.Overexpression of CDT1 Is a Predictor of Poor Survival in Patients with Hepatocellular Carcinoma.A Large-Scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells.Protein neddylation and its alterations in human cancers for targeted therapy.RING box protein-1 gene involved in flagellar disassembly of Dunaliella salina.

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P2860

RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins

http://www.wikidata.org/entity/Q30498021

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

RBX1 (RING box protein 1) E3 u ...... replication licensing proteins

@ast

RBX1 (RING box protein 1) E3 u ...... replication licensing proteins

@en

type

label

RBX1 (RING box protein 1) E3 u ...... replication licensing proteins

@ast

RBX1 (RING box protein 1) E3 u ...... replication licensing proteins

@en

prefLabel

RBX1 (RING box protein 1) E3 u ...... replication licensing proteins

@ast

RBX1 (RING box protein 1) E3 u ...... replication licensing proteins

@en

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JBC.M110.188425

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Journal of Biological Chemistry

P1476

RBX1 (RING box protein 1) E3 u ...... replication licensing proteins

@en

P2093

Hua Li

http://www.w3.org/2001/XMLSchema#string

Jeremy S Bickel

http://www.w3.org/2001/XMLSchema#string

Jiaxue Wu

http://www.w3.org/2001/XMLSchema#string

Jie Yang

http://www.w3.org/2001/XMLSchema#string

Lijun Jia

http://www.w3.org/2001/XMLSchema#string

Meredith A Morgan

http://www.w3.org/2001/XMLSchema#string

Xiaochun Yu

http://www.w3.org/2001/XMLSchema#string

Yi Sun

http://www.w3.org/2001/XMLSchema#string

P2860

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

Mechanisms to control rereplication and implications for cancer.

ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and bivalent formation in C. elegans

RING domain E3 ubiquitin ligases

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3379-3386

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scholarly article

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10.1074/JBC.M110.188425

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P433

5

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286

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P577

2010-11-29T00:00:00Z

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21115485

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P932

3030344

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