Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice - Wikidata - awgldk - TriplyDB

Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice

Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice

http://www.wikidata.org/entity/Q30499302

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Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function Neonatal Seizures: Impact on Neurodevelopmental Outcomes Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement.Stochastic model of Tsc1 lesions in mouse brain Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia.Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models.Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity.Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control.Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR.The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis.mTOR signaling in epilepsy: insights from malformations of cortical development Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities.Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion.Epilepsy as a neurodevelopmental disorder.Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTOR in vivo.Newborn cortical neurons: only for neonates?Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis.Diaschisis: An Old Concept Brought to New Life Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons.Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference.An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model.A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain.Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration.Fetal brain mTOR signaling activation in tuberous sclerosis complex.Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.Translational research: Rett syndrome and tuberous sclerosis complex.Are developmental dysplastic lesions epileptogenic?mTOR signaling in neural stem cells: from basic biology to disease.Evolving neurobiology of tuberous sclerosis complex.mTOR signaling and its roles in normal and abnormal brain development.Genetic animal models of malformations of cortical development and epilepsy.

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Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice

http://www.wikidata.org/entity/Q30499302

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Single-cell Tsc1 knockout duri ...... uces seizure threshold in mice

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Single-cell Tsc1 knockout duri ...... uces seizure threshold in mice

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type

label

Single-cell Tsc1 knockout duri ...... uces seizure threshold in mice

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Single-cell Tsc1 knockout duri ...... uces seizure threshold in mice

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prefLabel

Single-cell Tsc1 knockout duri ...... uces seizure threshold in mice

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Single-cell Tsc1 knockout duri ...... uces seizure threshold in mice

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Journal of Clinical Investigation

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Single-cell Tsc1 knockout duri ...... uces seizure threshold in mice

@en

P2093

Angélique Bordey

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David M Feliciano

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Jean Lopez

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Jean-Claude Platel

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Tiffany Su

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P2860

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

Identification and characterization of the tuberous sclerosis gene on chromosome 16

Unique morphological features of the proliferative zones and postmitotic compartments of the neural epithelium giving rise to striate and extrastriate cortex in the monkey

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes

Neurogenic radial glia in the outer subventricular zone of human neocortex

Neuronal subtype specification in the cerebral cortex

The tuberous sclerosis complex

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4

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121

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2011-03-14T00:00:00Z

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3069783

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