Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.
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Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum DisordersSomatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia.The genomic landscape of tuberous sclerosis complexWONOEP appraisal: Development of epilepsy biomarkers-What we can learn from our patients?Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC).Epilepsy Mechanisms in Neurocutaneous Disorders: Tuberous Sclerosis Complex, Neurofibromatosis Type 1, and Sturge-Weber Syndrome.mTOR inhibition in epilepsy: rationale and clinical perspectives.Genetic animal models of malformations of cortical development and epilepsy.Ionotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex.Tuberous sclerosis complex: From molecular biology to novel therapeutic approaches.High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex.Tuber-Less Models of Tuberous Sclerosis Still Provide Insights Into Epilepsy.Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling.Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs.Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability.A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.Electrophysiological Investigation of NMDA Current Properties in Brain Slices.Quantification of NMDAR Subunit Genes Expression by qRT-PCR.Epilepsy in young Tsc1(+/-) mice exhibits age-dependent expression that mimics that of human tuberous sclerosis complex.Vesicular glutamate release from central axons contributes to myelin damage.
P2860
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P2860
Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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name
Selective suppression of exces ...... berous sclerosis murine model.
@ast
Selective suppression of exces ...... berous sclerosis murine model.
@en
type
label
Selective suppression of exces ...... berous sclerosis murine model.
@ast
Selective suppression of exces ...... berous sclerosis murine model.
@en
prefLabel
Selective suppression of exces ...... berous sclerosis murine model.
@ast
Selective suppression of exces ...... berous sclerosis murine model.
@en
P2093
P2860
P50
P356
P1476
Selective suppression of exces ...... uberous sclerosis murine model
@en
P2093
A J Becker
D Scavarda
E Pallesi-Pocachard
G Dorfmuller
N Burnashev
P2860
P2888
P356
10.1038/NCOMMS5563
P407
P577
2014-08-01T00:00:00Z
P5875
P6179
1008024970