Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells.
about
Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndromeTherapeutic Targeting of TelomeraseEndoreplication and polyploidy: insights into development and diseaseDNA damage associated with mitosis and cytokinesis failureRoles and mechanisms of cellular senescence in regulation of tissue homeostasisA tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazoleDocetaxel-induced polyploidization may underlie chemoresistance and disease relapseSenescence from G2 arrest, revisitedMammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrityTranscriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications.TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeresFailure of cell cleavage induces senescence in tetraploid primary cells.Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathwayTransient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability.Causes and consequences of centrosome abnormalities in cancer.Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.The expanding implications of polyploidy.A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERTCytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice.Chromothripsis and Kataegis Induced by Telomere CrisisParasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicansPaired exome analysis of Barrett's esophagus and adenocarcinoma.Linking abnormal mitosis to the acquisition of DNA damageA three-state model of telomere control over human proliferative boundaries.Complex interactions between the DNA-damage response and mammalian telomeres.Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.Recent discoveries in the cycling, growing and aging of the p53 fieldTetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replicationRecent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis.Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.Medulloblastomics: the end of the beginning.Linking genomic reorganization to tumor initiation via the giant cell cycleUnderstanding telomere diseases through analysis of patient-derived iPS cells.Three-dimensional telomere dynamics in follicular thyroid cancerHeterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells.The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis.Genetic instability: tipping the balance.
P2860
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P2860
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Telomere-driven tetraploidizat ...... transformation of mouse cells.
@ast
Telomere-driven tetraploidizat ...... transformation of mouse cells.
@en
type
label
Telomere-driven tetraploidizat ...... transformation of mouse cells.
@ast
Telomere-driven tetraploidizat ...... transformation of mouse cells.
@en
prefLabel
Telomere-driven tetraploidizat ...... transformation of mouse cells.
@ast
Telomere-driven tetraploidizat ...... transformation of mouse cells.
@en
P2860
P1433
P1476
Telomere-driven tetraploidizat ...... transformation of mouse cells.
@en
P2860
P304
P356
10.1016/J.CCR.2012.03.044
P577
2012-06-01T00:00:00Z