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ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic InstabilityPotential epigenetic mechanism(s) associated with the persistence of psychoneurological symptoms in women receiving chemotherapy for breast cancer: a hypothesisVisualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors.Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues.Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability.Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiaeThe cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective.Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability.Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age.Kinetochore-microtube attachments in cancer therapy.Identification of large-scale genomic variation in cancer genomes using in silico reference modelsEnriching CRISPR-Cas9 targeted cells by co-targeting the HPRT gene.Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression.Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.Different promoter affinities account for specificity in MYC-dependent gene regulation.A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin.Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid NeoplasiaDesign and development of therapies using chimeric antigen receptor-expressing T cellsGlobal analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancersIonizing radiation-induced oxidative stress, epigenetic changes and genomic instability: the pivotal role of mitochondria.Bacterial protein toxins in human cancers.Targeting mitotic pathways for endocrine-related cancer therapeutics.The Elephant in the Room: The Role of Microtubules in Cancer.Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing.The genomic dynamics during progression of lung adenocarcinomasTreatment-Induced Mutagenesis and Selective Pressures Sculpt Cancer Evolution.Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.Exploiting DNA repair defects for novel cancer therapies.New Approaches in CAR-T Cell Immunotherapy for Breast Cancer.Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization.Multiple oncogenic roles of nuclear beta-catenin.The macro-evolutionary events in esophageal squamous cell carcinoma.N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore-microtubule dynamics.Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1.Biomarkers: paving stones on the road towards the personalized precision medicine for oral squamous cell carcinoma
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Genetic instability: tipping the balance.
@en
type
label
Genetic instability: tipping the balance.
@en
prefLabel
Genetic instability: tipping the balance.
@en
P2860
P356
P1433
P1476
Genetic instability: tipping the balance.
@en
P2860
P2888
P304
P356
10.1038/ONC.2012.576
P407
P577
2012-12-17T00:00:00Z
P5875
P6179
1009897033