SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.
about
TPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release.SNAREs in the maturation and function of LROsMegakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiationMutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neuronsBLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriersMKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation.Congenital platelet disorders and understanding of platelet function.Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules.Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes.Megakaryocytic Maturation in Response to Shear Flow Is Mediated by the Activator Protein 1 (AP-1) Transcription Factor via Mitogen-activated Protein Kinase (MAPK) Mechanotransduction.Lysosome-related organelles: unusual compartments become mainstream.SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation.Hypopigmentation in Hermansky-Pudlak syndrome.Platelet secretory behaviour: as diverse as the granules … or not?Storage pool diseases illuminate platelet dense granule biogenesis.Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.Dynamic of contribution of UBPy-sorted cargo to acrosome biogenesis: effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant.The life cycle of platelet granules.Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formationSorting machineries: how platelet-dense granules differ from α-granules
P2860
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P2860
SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
SLC35D3 delivery from megakary ...... mansky-Pudlak syndrome models.
@ast
SLC35D3 delivery from megakary ...... mansky-Pudlak syndrome models.
@en
type
label
SLC35D3 delivery from megakary ...... mansky-Pudlak syndrome models.
@ast
SLC35D3 delivery from megakary ...... mansky-Pudlak syndrome models.
@en
prefLabel
SLC35D3 delivery from megakary ...... mansky-Pudlak syndrome models.
@ast
SLC35D3 delivery from megakary ...... mansky-Pudlak syndrome models.
@en
P2093
P2860
P1433
P1476
SLC35D3 delivery from megakary ...... rmansky-Pudlak syndrome models
@en
P2093
Anand Sitaram
Dawn C Harper
Graça Raposo
Harry F G Heijnen
Mortimer Poncz
Ronghua Meng
Yuhuan Wang
P2860
P304
P356
10.1182/BLOOD-2011-11-389551
P407
P577
2012-05-18T00:00:00Z