Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome. - Wikidata - awgldk - TriplyDB

Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.

Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.

http://www.wikidata.org/entity/Q30525665

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Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes Regulation of actin nucleation and autophagosome formation Myosins, Actin and Autophagy Protein homeostasis at the plasma membrane Therapeutic targeting of autophagy in neurodegenerative and infectious diseases The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion.Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.The TBK1-binding domain of optineurin promotes type I interferon responses LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes.Distinct Contributions of Autophagy Receptors in Measles Virus Replication Evaluation of ERG responsive proteome in prostate cancer Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.Autophagy stimulation abrogates herpes simplex virus-1 infection Structure biology of selective autophagy receptors.Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients Alteration of lysosome fusion and low-grade inflammation mediated by super-low-dose endotoxin.Herpes Simplex Virus-1 Fine-Tunes Host's Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models.Mitofusin 2-deficiency suppresses cell proliferation through disturbance of autophagy.Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene.Proteomics of Primary Cilia by Proximity Labeling Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism.Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences.NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1.Calcium gets myosin VI ready for work Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2.Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.Myosin VI in skeletal muscle: its localization in the sarcoplasmic reticulum, neuromuscular junction and muscle nuclei.Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus.Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes.A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells.Receptor for Activated C Kinase 1 (RACK1) Promotes Dishevelled Protein Degradation via Autophagy and Antagonizes Wnt Signaling Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain Myosin 6 is required for iris development and normal function of the outer retina.Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

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Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.

http://www.wikidata.org/entity/Q30525665

description

2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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name

Autophagy receptors link myosi ...... and fusion with the lysosome.

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Autophagy receptors link myosi ...... and fusion with the lysosome.

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type

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Autophagy receptors link myosi ...... and fusion with the lysosome.

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Autophagy receptors link myosi ...... and fusion with the lysosome.

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Autophagy receptors link myosi ...... and fusion with the lysosome.

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Autophagy receptors link myosi ...... and fusion with the lysosome.

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Nature Cell Biology

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Autophagy receptors link myosi ...... and fusion with the lysosome.

@en

P2093

Bennett J Waxse

http://www.w3.org/2001/XMLSchema#string

David A Tumbarello

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Folma Buss

http://www.w3.org/2001/XMLSchema#string

John Kendrick-Jones

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Nicholas A Bright

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Susan D Arden

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P2860

The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

Subversion of cellular autophagosomal machinery by RNA viruses.

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat

T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion.

How are the cellular functions of myosin VI regulated within the cell?

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1024-1035

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10.1038/NCB2589

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10

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14

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1014834753

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23023224

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