Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells. - Wikidata - awgldk - TriplyDB

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

http://www.wikidata.org/entity/Q37455356

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Functional analysis of optineurin and some of its disease-associated mutants Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics The TBK1-binding domain of optineurin promotes type I interferon responses Inhibition of Extracellular Calcium Influx Results in Enhanced IL-12 Production in LPS-Treated Murine Macrophages by Downregulation of the CaMKKβ-AMPK-SIRT1 Signaling Pathway RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients Optineurin regulates the interferon response in a cell cycle-dependent manner Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing.Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget's Disease Effects of mutations and deletions in the human optineurin gene.Immune diseases caused by mutations in kinases and components of the ubiquitin system.Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.Inducible turnover of optineurin regulates T cell activation.Optineurin Functions for Optimal Immunity.The Role of Optineurin in Antiviral Type I Interferon Production.The Selective Autophagy Receptor Optineurin in Crohn's Disease.Molecular effect of an OPTN common variant associated to Paget's disease of bone.Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer.Fecal Microbiota Transplantation Beneficially Regulates Intestinal Mucosal Autophagy and Alleviates Gut Barrier Injury Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer

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Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

http://www.wikidata.org/entity/Q37455356

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年学术文章

@wuu

2013年学术文章

@zh-cn

2013年学术文章

@zh-hans

2013年学术文章

@zh-my

2013年学术文章

@zh-sg

2013年學術文章

@yue

2013年學術文章

@zh

2013年學術文章

@zh-hant

name

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

@en

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

@nl

type

label

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

@en

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

@nl

prefLabel

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

@en

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

@nl

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P356

JIMMUNOL.1301696

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Journal of Immunology

P1476

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

@en

P2093

Caiyi C Li

http://www.w3.org/2001/XMLSchema#string

Guozhi Zhu

http://www.w3.org/2001/XMLSchema#string

Jonathan D Ashwell

http://www.w3.org/2001/XMLSchema#string

Maria Letizia Giardino Torchia

http://www.w3.org/2001/XMLSchema#string

P2860

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

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6231-6240

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scholarly article

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10.4049/JIMMUNOL.1301696

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12

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191

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Netra Pal Meena

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