Distinct signalling pathways control Toxoplasma egress and host-cell invasion
about
Recent insights into apicomplexan parasite egress provide new views to a killChemical biology approaches for the study of apicomplexan parasitesThe calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium sppUsing a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egressNeospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapyA Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan GenesPhosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasitesPhosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egressCell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replicationCalcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondiiSerum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondiiPlasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondiiToxoplasma gondii Hsp90: potential roles in essential cellular processes of the parasite.Genetic basis for phenotypic differences between different Toxoplasma gondii type I strainsSmall-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion.Plasmodium berghei calcium dependent protein kinase 1 is not required for host cell invasion.The apical complex provides a regulated gateway for secretion of invasion factors in Toxoplasma.The calcium-dependent protein kinase 3 of toxoplasma influences basal calcium levels and functions beyond egress as revealed by quantitative phosphoproteome analysisEfficient genome engineering of Toxoplasma gondii using CRISPR/Cas9.Acidification Activates Toxoplasma gondii Motility and Egress by Enhancing Protein Secretion and Cytolytic ActivityGenome-wide expression patterns of calcium-dependent protein kinases in Toxoplasma gondii.Allosteric activation of apicomplexan calcium-dependent protein kinases.Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.Monitoring of dynamin during the Toxoplasma gondii cell cycle.Molecular Characterization and Functional Analysis of a Novel Calcium-Dependent Protein Kinase 4 from Eimeria tenellaLytic Cycle of Toxoplasma gondii: 15 Years Later.Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondiiGlobal Analysis of Palmitoylated Proteins in Toxoplasma gondii.Cytoplasmic free Ca2+ is essential for multiple steps in malaria parasite egress from infected erythrocytes.A Lipolytic Lecithin:Cholesterol Acyltransferase Secreted by Toxoplasma Facilitates Parasite Replication and EgressImidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.Functional dissection of Toxoplasma gondii perforin-like protein 1 reveals a dual domain mode of membrane binding for cytolysis and parasite egressAnalysis of Noncanonical Calcium-Dependent Protein Kinases in Toxoplasma gondii by Targeted Gene Deletion Using CRISPR/Cas9.Serial Dissection of Parasite Gene Families.Exploiting the unique ATP-binding pocket of toxoplasma calcium-dependent protein kinase 1 to identify its substrates.A novel protein kinase is essential in bloodstream Trypanosoma bruceiReview of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugsDesigning selective inhibitors for calcium-dependent protein kinases in apicomplexans.
P2860
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P2860
Distinct signalling pathways control Toxoplasma egress and host-cell invasion
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Distinct signalling pathways control Toxoplasma egress and host-cell invasion
@ast
Distinct signalling pathways control Toxoplasma egress and host-cell invasion
@en
type
label
Distinct signalling pathways control Toxoplasma egress and host-cell invasion
@ast
Distinct signalling pathways control Toxoplasma egress and host-cell invasion
@en
prefLabel
Distinct signalling pathways control Toxoplasma egress and host-cell invasion
@ast
Distinct signalling pathways control Toxoplasma egress and host-cell invasion
@en
P2860
P356
P1433
P1476
Distinct signalling pathways control Toxoplasma egress and host-cell invasion
@en
P2093
Keliang Tang
Sebastian Lourido
P2860
P304
P356
10.1038/EMBOJ.2012.299
P407
P577
2012-11-13T00:00:00Z