Two modes of integrin activation form a binary molecular switch in adhesion maturation - Wikidata - awgldk - TriplyDB

Two modes of integrin activation form a binary molecular switch in adhesion maturation

Two modes of integrin activation form a binary molecular switch in adhesion maturation

http://www.wikidata.org/entity/Q30539304

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Integrin cytoplasmic tail interactions Vinculin controls talin engagement with the actomyosin machinery.All Subdomains of the Talin Rod Are Mechanically Vulnerable and May Contribute To Cellular Mechanosensing Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions Vinculin in cell-cell and cell-matrix adhesions.Talins and kindlins: partners in integrin-mediated adhesion.CXCL12 Modulates Prostate Cancer Cell Adhesion by Altering the Levels or Activities of β1-Containing Integrins.Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility.Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation.Mechanisms of talin-dependent integrin signaling and crosstalk Mechanical control of the endothelial barrier.The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix.The Rap1-RIAM-talin axis of integrin activation and blood cell function Non-monotonic cellular responses to heterogeneity in talin protein expression-level.Single and collective cell migration: the mechanics of adhesions.Talin - the master of integrin adhesions.Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.The Rap1-RIAM pathway prefers β2 integrins Talin autoinhibition is required for morphogenesis.SnapShot: talin and the modular nature of the integrin adhesome.Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation

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Two modes of integrin activation form a binary molecular switch in adhesion maturation

http://www.wikidata.org/entity/Q30539304

description

2013 nî lūn-bûn

@nan

2013 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի մարտին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Two modes of integrin activation form a binary molecular switch in adhesion maturation

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Two modes of integrin activation form a binary molecular switch in adhesion maturation

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type

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Two modes of integrin activation form a binary molecular switch in adhesion maturation

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Two modes of integrin activation form a binary molecular switch in adhesion maturation

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prefLabel

Two modes of integrin activation form a binary molecular switch in adhesion maturation

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Two modes of integrin activation form a binary molecular switch in adhesion maturation

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MBC.E12-09-0695

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Molecular Biology of the Cell

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Two modes of integrin activation form a binary molecular switch in adhesion maturation

@en

P2093

Chi-Chao Liu

http://www.w3.org/2001/XMLSchema#string

Ho-Sup Lee

http://www.w3.org/2001/XMLSchema#string

Mark H Ginsberg

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Praju Anekal

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P2860

Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses

Structural determinants of integrin recognition by talin

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

FAK promotes recruitment of talin to nascent adhesions to control cell motility

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics

RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

Nanoscale architecture of integrin-based cell adhesions

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation.

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1354-1362

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scholarly article

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10.1091/MBC.E12-09-0695

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9

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24

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Chinten James Lim

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2013-03-06T00:00:00Z

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23468527

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3639047

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