Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.
about
T cell antigen recognition at the cell membraneStructural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-EDistinct temporal patterns of T cell receptor signaling during positive versus negative selection in situQuantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Organization of proximal signal initiation at the TCR:CD3 complex.Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell developmentPeptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.How the immune system talks to itself: the varied role of synapsesDampening of death pathways by schnurri-2 is essential for T-cell development.On the issue of peptide recognition in T cell development.Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction.Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.Functional development of the T cell receptor for antigenT cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181aCD6 modulates thymocyte selection and peripheral T cell homeostasisA single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells.Molecular and genetic parameters defining T-cell clonal selection.Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes.Toward quantifying the thymic dysfunctional state in mouse models of inflammatory bowel disease.The actin-driven spatiotemporal organization of T-cell signaling at the system scale.Mechanosensing drives acuity of αβ T-cell recognition.Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.
P2860
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P2860
Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Low ligand requirement for del ...... t of thymic T cell maturation.
@ast
Low ligand requirement for del ...... t of thymic T cell maturation.
@en
type
label
Low ligand requirement for del ...... t of thymic T cell maturation.
@ast
Low ligand requirement for del ...... t of thymic T cell maturation.
@en
prefLabel
Low ligand requirement for del ...... t of thymic T cell maturation.
@ast
Low ligand requirement for del ...... t of thymic T cell maturation.
@en
P2093
P2860
P1433
P1476
Low ligand requirement for del ...... t of thymic T cell maturation.
@en
P2093
Lauren I Richie Ehrlich
Mark M Davis
Peter J R Ebert
P2860
P304
P356
10.1016/J.IMMUNI.2008.09.014
P407
P577
2008-11-01T00:00:00Z