Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.
about
Diseases caused by mutations in ORAI1 and STIM1Accumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cells.Fine-tuning T cell receptor signaling to control T cell developmentElevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage.Jarid2 is induced by TCR signalling and controls iNKT cell maturation.The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling.Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic CellsSTIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.Ion channels in innate and adaptive immunityStore-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and AutoimmunityIon channels and anti-cancer immunity.ORAI2 modulates store-operated calcium entry and T cell-mediated immunityEmerging roles of store-operated Ca²⁺ entry through STIM and ORAI proteins in immunity, hemostasis and cancer.Weft, warp, and weave: the intricate tapestry of calcium channels regulating T lymphocyte function.The critical role of STIM1-dependent Ca2+ signalling during T-cell development and activation.The role of FOXP3 in regulating immune responses.Tweeters, Woofers and Horns: The Complex Orchestration of Calcium Currents in T Lymphocytes.Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.Transcriptional modulation of regulatory T cell development by novel regulators NR4As.Role of STIM2 in cell function and physiopathology.Ca(2+) influx in T cells: how many ca(2+) channels?Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models.Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota.Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis.Measurement of intracellular ions by flow cytometry.Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation.Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection.Novel STIM1-dependent control of Ca2+ clearance regulates NFAT activity during T-cell activation.Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4+ T cells and human leukaemic T cell lymphoblasts.ORAI1 mutations abolishing store-operated Ca2+ entry cause anhidrotic ectodermal dysplasia with immunodeficiency.Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells.Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes.Inhibition of CRAC with a human anti-ORAI1 monoclonal antibody inhibits T-cell-derived cytokine production but fails to inhibit a T-cell-dependent antibody response in the cynomolgus monkey.Ion channelopathies of the immune system.A committed postselection precursor to natural TCRαβ+ intraepithelial lymphocytes.The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts.M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium EntryNF-κB factors control the induction of NFATc1 in B lymphocytes
P2860
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P2860
Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Agonist-selected T cell develo ...... store-operated calcium entry.
@en
type
label
Agonist-selected T cell develo ...... store-operated calcium entry.
@en
prefLabel
Agonist-selected T cell develo ...... store-operated calcium entry.
@en
P2093
P2860
P1433
P1476
Agonist-selected T cell develo ...... d store-operated calcium entry
@en
P2093
Anjana Rao
Hiroshi Takayanagi
Masaru Taniguchi
Masatsugu Oh-Hora
Mojgan Pishyareh
Noriko Komatsu
P2860
P304
P356
10.1016/J.IMMUNI.2013.02.008
P407
P577
2013-03-14T00:00:00Z