Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. - Wikidata - awgldk - TriplyDB

Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.

Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.

http://www.wikidata.org/entity/Q30545790

about

Mechanisms of Aβ Clearance and Degradation by Glial Cells Role of the Retromer Complex in Neurodegenerative Diseases Alzheimer's Disease: Mechanism and Approach to Cell Therapy Autophagy and neurodegeneration Autophagy in the physiology and pathology of the central nervous system Sorting through the roles of beclin 1 in microglia and neurodegeneration The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages.ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes Neuroinflammation in Alzheimer's disease Cargo trafficking in Alzheimer’s disease: the possible role of retromer Inflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease during 24 Months of Follow-Up Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor Microglia as a critical player in both developmental and late-life CNS pathologies.Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability.The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.Microglia change from a reactive to an age-like phenotype with the time in culture Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome.Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance GA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genes Prostaglandin E2 receptor subtype 2 regulation of scavenger receptor CD36 modulates microglial Aβ42 phagocytosis.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.The evolving biology of microglia in Alzheimer's disease.Intravenous infusion of monocytes isolated from 2-week-old mice enhances clearance of Beta-amyloid plaques in an Alzheimer mouse model Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology Beclin 1 biology and its role in heart disease.Redox regulation of autophagy in healthy brain and neurodegeneration.Alginate-Derived Oligosaccharide Inhibits Neuroinflammation and Promotes Microglial Phagocytosis of β-Amyloid.Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures.BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5.Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.Increased tauopathy drives microglia-mediated clearance of beta-amyloid.

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P2860

Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.

http://www.wikidata.org/entity/Q30545790

description

2013 nî lūn-bûn

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2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Microglial beclin 1 regulates ...... paired in Alzheimer's disease.

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Microglial beclin 1 regulates ...... paired in Alzheimer's disease.

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Microglial beclin 1 regulates ...... paired in Alzheimer's disease.

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Microglial beclin 1 regulates ...... paired in Alzheimer's disease.

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J.NEURON.2013.06.046

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Microglial beclin 1 regulates ...... paired in Alzheimer's disease.

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Brian Spencer

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Caitlin E O'Brien

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Diego F Mastroeni

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Eva Czirr

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Gregor Bieri

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Joseph Rogers

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Kira I Mosher

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Kurt M Lucin

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Rachelle J Abbey

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Tony Wyss-Coray

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P2860

TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

Network organization of the human autophagy system

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Autophagy in immunity and inflammation

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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873-886

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scholarly article

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10.1016/J.NEURON.2013.06.046

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5

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Eliezer Masliah

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256467799

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24012002

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Alzheimer's disease

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3779465

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