Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy. - Wikidata - awgldk - TriplyDB

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

http://www.wikidata.org/entity/Q33920691

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Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice LRRK2 at the interface of autophagosomes, endosomes and lysosomes Autophagosome dynamics in neurodegeneration at a glance Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1 LRRK2 levels in immune cells are increased in Parkinson's disease Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.Herb-Partitioned Moxibustion and the miRNAs Related to Crohn's Disease: A Study Based on Rat Models.The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease.Decoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation.Autophagy-related gene LRRK2 is likely a susceptibility gene for systemic lupus erythematosus in northern Han Chinese.Cellular processes associated with LRRK2 function and dysfunction Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.LRRK2 and Autophagy.Sec16 in conventional and unconventional exocytosis: Working at the interface of membrane traffic and secretory autophagy?LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies.LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.The LRRK2-macroautophagy axis and its relevance to Parkinson's disease LRRK2 and the Immune System.Targeting LRRK2 in Parkinson's disease: an update on recent developments.Computational analysis of the LRRK2 interactome.An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease.Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells.Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.Autophagy impairment in Parkinson's disease.The functional roles of retromer in Parkinson's disease.LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants.Mechanisms of Mutant LRRK2 Neurodegeneration.Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.Interaction of LRRK2 and α-Synuclein in Parkinson's Disease.

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P2860

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

http://www.wikidata.org/entity/Q33920691

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

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Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

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type

label

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

@ast

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

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prefLabel

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

@ast

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

@en

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Human Molecular Genetics

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Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.

@en

P2093

Fredrik Felizia

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Jason Schapansky

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Jonathan D Nardozzi

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Matthew J LaVoie

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

Interplay of LRRK2 with chaperone-mediated autophagy

LRRK2 regulates synaptic vesicle endocytosis

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4201-4214

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10.1093/HMG/DDU138

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16

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23

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