Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro - Wikidata - awgldk - TriplyDB

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro

http://www.wikidata.org/entity/Q30558754

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Targeting the latent reservoir to achieve functional HIV cure Contemporary Strategies for the Synthesis of Tetrahydropyran Derivatives: Application to Total Synthesis of Neopeltolide, a Marine Macrolide Natural Product Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis The Role of PKC-θ in CD4+ T Cells and HIV Infection: To the Nucleus and Back Again Emerging strategies to deplete the HIV reservoir Targeting NF-κB signaling with protein kinase C agonists as an emerging strategy for combating HIV latency An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1 Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery.Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core Exploring the potential of monoclonal antibody therapeutics for HIV-1 eradication.Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold.Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4(+) T Cells from Aviremic Patients.Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells.Euphorbia Kansui Reactivates Latent HIV.Mechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization.Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal CRISPR-mediated Activation of Latent HIV-1 Expression HIV/AIDS eradication Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo.The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication.Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ-NF-κB signaling.Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death.Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway.Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

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P2860

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro

http://www.wikidata.org/entity/Q30558754

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2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Designed, synthetically access ...... latent HIV reservoirs in vitro

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Designed, synthetically access ...... latent HIV reservoirs in vitro

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Designed, synthetically access ...... latent HIV reservoirs in vitro

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Nature Chemistry

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Designed, synthetically access ...... latent HIV reservoirs in vitro

@en

P2093

Adam J Schrier

http://www.w3.org/2001/XMLSchema#string

Brian A DeChristopher

http://www.w3.org/2001/XMLSchema#string

Brian A Loy

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Jerome A Zack

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Matthew D Marsden

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Paul A Wender

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P2860

Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells

Total synthesis of bryostatin 7 via C-C bond-forming hydrogenation

Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV

Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators

Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner

Activation of latent HIV using drug-loaded nanoparticles

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy.

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C

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705-710

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10.1038/NCHEM.1395

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9

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4

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2012-07-15T00:00:00Z

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230722053

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1003957031

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22914190

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3428736

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