Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy.
about
Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1Total synthesis of bryostatin 7 via C-C bond-forming hydrogenationFormal synthesis of (-)-kendomycin featuring a Prins-cyclization to construct the macrocycleTotal synthesis of bryostatin 16 using atom-economical and chemoselective approachesCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisDesigned, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitroNatural Products as a Foundation for Drug Discovery.Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent.Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivityFeCl3-Catalyzed Tandem Prins and Friedel-Crafts Cyclization: A Highly Diastereoselective Route to Polycyclic Ring Structures.Mechanistic Analysis of Oxidative C-H Cleavages Using Inter- and Intramolecular Kinetic Isotope EffectsSymmetric macrocycles by a Prins dimerization and macrocyclization strategy.Total synthesis of neopeltolide and analogsTotal synthesis of bryostatin 9Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreTranslating Nature's Library: The Bryostatins and Function-Oriented SynthesisTotal synthesis of bryostatin 1Total synthesis of the cyanolide A aglycon.Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopyPhase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant."Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo.Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.Total syntheses of bryostatins: synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment.Atom-economic and stereoselective syntheses of the ring a and B subunits of the bryostatins.Mechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization.Natural products as a source of Alzheimer's drug leads.Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.Oxidative carbocation formation in macrocycles: synthesis of the neopeltolide macrocycle.Enantioselective total synthesis of (-)-acutumine.Prins-type macrocyclizations as an efficient ring-closing strategy in natural product synthesis.Probing the biology of natural products: molecular editing by diverted total synthesis.The medicinal potential of promising marine macrolides with anticancer activity.Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Natural Products and Their Mimics as Targets of Opportunity for Discovery.Natural product analogues: towards a blueprint for analogue-focused synthesis.Enantioselective synthesis of (-)-exiguolide by iterative stereoselective dioxinone-directed Prins cyclizations.Total synthesis and structure-activity investigation of the marine natural product neopeltolide.
P2860
Q24599839-FC4FA019-CBD6-404F-BE9A-9A3BD91F151EQ24607710-5EDCFC9A-C7E8-4CAC-A9D2-89A788D91E06Q24644824-26029D82-6385-4D91-9C3C-E41A070243C2Q24649951-C92E440C-6EF6-42DA-998E-997828275C5DQ26772873-D4D6E2CF-49ED-41F3-9742-992F67B595AFQ30558754-04ACE195-1DB4-4C9C-B986-3F8B2664CAF3Q33617301-FBD623CE-6612-46C0-B352-36144DD09746Q33736184-8581CB1A-95DF-4671-9952-5F68BC43E80BQ33849709-69AD1F93-DE37-44C9-9740-20A0B55C306DQ33996863-3DA6AD68-6FD5-452D-895A-26F2C8FA4B19Q33997432-8FD26E34-BFC3-4E44-8EB5-941D1D2D3C6BQ34001566-A9B1DB98-CE4F-4DF5-86D7-6BE17B161DD7Q34048909-69FF2CDC-2F5C-469D-8670-4B14131944C7Q34187866-F30B52C2-F7F2-46D4-AEEA-2DC959F257ABQ34282542-7C38CD66-FA31-413E-8507-D2101A71D1B1Q34282624-358957EF-9F18-452B-8361-A9BF1C026D3EQ34290699-06530F0C-0892-4249-B189-60A15D7B2F0DQ34538229-DF7AC461-EE52-442E-90A2-B33419DD8C26Q35097674-F7A93C82-A17E-44EF-AD0D-4BC0A287764FQ35132573-EF4C9953-49A5-4310-B72A-6F33B7BDA79BQ35511561-36049913-0EC4-4023-9C84-C0091A09232DQ35733482-55E503A4-321E-4252-85FD-2874FAFD258DQ35799776-E7CE6443-5B68-44CB-960B-084B5BDAFB05Q36156057-E9DF707C-7A94-4F18-AA70-3D40FF5DC156Q36452817-8DB6CD98-5205-4A9C-A1C0-205651857CD4Q36452840-9384C535-E8F6-43D6-B845-A91114DCEA08Q36510954-B8B36856-A91E-4E60-9E15-0D6165E7E39EQ37029561-88B2C031-AED2-44A7-BDCC-F42942F56207Q37095319-028F067D-C87E-46AA-B94E-E14381ABE113Q37348332-2EE9502C-6717-4564-9A86-6DC18CC98B42Q37465414-A2E4E63A-7E75-4E14-907F-4D40C1CDBEDEQ37798770-C63BCC1A-2EAB-45EC-ADFE-30F5D7C641B5Q37809500-8221E690-794E-4F86-9CAE-5AD8225832ACQ37837738-83539EED-883C-43AE-8B59-A32AF5C6B0DFQ38005950-8ED7FBC9-40D1-4CFD-AEC3-A33FAA1035A0Q38200047-0622F8DB-3EE0-4078-861D-09E31C1701E0Q38557129-FEDCCD10-DDF6-4069-BF35-FAA218D52048Q39413228-D196B8A0-4B0D-4CDE-88F3-3B3583119CCFQ39471184-3987BA1C-B276-4391-90D7-86763D41FCBDQ39815422-1C50D20A-9DAC-43B4-9C03-E524D32680F7
P2860
Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Efficient synthetic access to ...... ven macrocyclization strategy.
@ast
Efficient synthetic access to ...... ven macrocyclization strategy.
@en
Efficient synthetic access to ...... ven macrocyclization strategy.
@nl
type
label
Efficient synthetic access to ...... ven macrocyclization strategy.
@ast
Efficient synthetic access to ...... ven macrocyclization strategy.
@en
Efficient synthetic access to ...... ven macrocyclization strategy.
@nl
prefLabel
Efficient synthetic access to ...... ven macrocyclization strategy.
@ast
Efficient synthetic access to ...... ven macrocyclization strategy.
@en
Efficient synthetic access to ...... ven macrocyclization strategy.
@nl
P2093
P2860
P356
P1476
Efficient synthetic access to ...... ven macrocyclization strategy.
@en
P2093
Adam J Schrier
Brian A Dechristopher
Paul A Wender
P2860
P304
P356
10.1021/JA8015632
P407
P577
2008-05-02T00:00:00Z