High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance.

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance.

Item
http://www.wikidata.org/entity/Q30577011
Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody.Characterization of the anti-factor VIII immunoglobulin profile in patients with hemophilia A by use of a fluorescence-based immunoassay.The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfacesHigh-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors.Engineering less immunogenic and antigenic FVIII proteins.Antibody Engineering for Pursuing a Healthier FutureLife in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A.T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire.The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.
P2860

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance.

Item
http://www.wikidata.org/entity/Q30577011
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
High-resolution mapping of epi ...... ing surface plasmon resonance.
@ast
High-resolution mapping of epi ...... ing surface plasmon resonance.
@en
type
label
High-resolution mapping of epi ...... ing surface plasmon resonance.
@ast
High-resolution mapping of epi ...... ing surface plasmon resonance.
@en
prefLabel
High-resolution mapping of epi ...... ing surface plasmon resonance.
@ast
High-resolution mapping of epi ...... ing surface plasmon resonance.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
High-resolution mapping of epi ...... ing surface plasmon resonance.
@en
P2093
P2860
P304
P31
P356
10.1182/BLOOD-2013-09-527275
P407
P433
P478
P50
P577
P5875
P698
P932