Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex
about
Trp2313-His2315 of Factor VIII C2 Domain Is Involved in Membrane Binding: STRUCTURE OF A COMPLEX BETWEEN THE C2 DOMAIN AND AN INHIBITOR OF MEMBRANE BINDINGDomain organization of membrane-bound factor VIII.Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for SignalingStructure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopesA network-based multi-target computational estimation scheme for anticoagulant activities of compoundsAnalysis of conformational variation in macromolecular structural modelsChanges in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IXReplacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXaCofactor activity in factor VIIIa of the blood clotting pathway is stabilized by an interdomain bond between His281 and Ser524 formed in factor VIII.Lipid nanotechnologies for structural studies of membrane-associated proteinsDimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes.High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance.Model-building strategies for low-resolution X-ray crystallographic dataStructural investigation of zymogenic and activated forms of human blood coagulation factor VIII: a computational molecular dynamics studyRole of hydrophobic mutations on the binding affinity and stability of blood coagulation factor VIIIa: a computational molecular dynamics and free-energy analysis.Clinical utility and patient perspectives on the use of extended half-life rFIXFc in the management of hemophilia B.Hemophilia: an amazing 35-year journey from the depths of HIV to the threshold of cureFactor VIII lacking the C2 domain retains cofactor activity in vitroLack of recombinant factor VIII B-domain induces phospholipid vesicle aggregation: implications for the immunogenicity of factor VIIIStructural insights into the interaction of blood coagulation co-factor VIIIa with factor IXa: a computational protein-protein docking and molecular dynamics refinement study.The molecular basis of factor V and VIII procofactor activationThe regulation of factor IXa by supersulfated low molecular weight heparin.Blood coagulation factors V and VIII: Molecular Mechanisms of Procofactor Activation.Membrane-induced structural rearrangement and identification of a novel membrane anchor in talin F2F3Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional proteinIncreasing hydrophobicity or disulfide bridging at the factor VIII A1 and C2 domain interface enhances procofactor stability.Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase.Accelerating membrane insertion of peripheral proteins with a novel membrane mimetic model.Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIIIConservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity.The diversity of the immune response to the A2 domain of human factor VIIIFactor VIIIa A2 subunit shows a high affinity interaction with factor IXa: contribution of A2 subunit residues 707-714 to the interaction with factor IXa.Membrane-binding properties of the Factor VIII C2 domain.Atomic-level description of protein-lipid interactions using an accelerated membrane model.Native-like aggregates of factor VIII are immunogenic in von Willebrand factor deficient and hemophilia a miceAchievements, challenges and unmet needs for haemophilia patients with inhibitors: Report from a symposium in Paris, France on 20 November 2014.Molecular approaches for improved clotting factors for hemophilia.Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXaThe C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells.
P2860
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P2860
Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@ast
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@en
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@nl
type
label
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@ast
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@en
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@nl
prefLabel
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@ast
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@en
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@nl
P2093
P1433
P1476
Crystal structure of human fac ...... actor IXa-factor VIIIa complex
@en
P2093
Barbara C Furie
Bruce Furie
David A Roth
Mingdong Huang
P304
P356
10.1016/J.STR.2008.03.001
P577
2008-04-01T00:00:00Z