Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.
about
Metazoan Hsp70-based protein disaggregases: emergence and mechanismsRegulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genesProtein Folding and Mechanisms of ProteostasisSorting out the trash: the spatial nature of eukaryotic protein quality controlYeast prions: structure, biology, and prion-handling systemsA huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease.Prion Aggregates Are Recruited to the Insoluble Protein Deposit (IPOD) via Myosin 2-Based Vesicular TransportThe protein quality control machinery regulates its misassembled proteasome subunitsModulation of the maladaptive stress response to manage diseases of protein foldingEssential genetic interactors of SIR2 required for spatial sequestration and asymmetrical inheritance of protein aggregatesFusion of protein aggregates facilitates asymmetric damage segregationA method to rapidly create protein aggregates in living cells.Cytoplasmic dynein is required for the spatial organization of protein aggregates in filamentous fungiPrefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility.Conformational analysis of misfolded protein aggregation by FRET and live-cell imaging techniquesEngineering enhanced protein disaggregases for neurodegenerative diseaseArtificial targeting of misfolded cytosolic proteins to endoplasmic reticulum as a mechanism for clearance.Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae.Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions.How the nucleus copes with proteotoxic stress.Widespread Proteome Remodeling and Aggregation in Aging C. elegans.Protein aggregation as a mechanism of adaptive cellular responses.Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing.Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition.Experimental ocean acidification alters the allocation of metabolic energyHeterologous aggregates promote de novo prion appearance via more than one mechanism.Analytical model for macromolecular partitioning during yeast cell divisionHsp70 clears misfolded kinases that partitioned into distinct quality-control compartments.Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast.Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity.Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated DegradationImaging stress.Prion aggregate structure in yeast cells is determined by the Hsp104-Hsp110 disaggregase machinery.TRIM32-Cytoplasmic-Body Formation Is an ATP-Consuming Process Stimulated by HSP70 in Cells.Proteomic Analysis of Dhh1 Complexes Reveals a Role for Hsp40 Chaperone Ydj1 in Yeast P-Body Assembly.Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [PSI+] prion formation.Role for Lipid Droplet Biogenesis and Microlipophagy in Adaptation to Lipid Imbalance in Yeast.Hsp90 Maintains Proteostasis of the Galactose Utilization Pathway To Prevent Cell LethalitySmall heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding.Protein misfolding in neurodegenerative diseases: implications and strategies.
P2860
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P2860
Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Spatial sequestration of misfo ...... ellular fitness during stress.
@ast
Spatial sequestration of misfo ...... ellular fitness during stress.
@en
type
label
Spatial sequestration of misfo ...... ellular fitness during stress.
@ast
Spatial sequestration of misfo ...... ellular fitness during stress.
@en
prefLabel
Spatial sequestration of misfo ...... ellular fitness during stress.
@ast
Spatial sequestration of misfo ...... ellular fitness during stress.
@en
P2860
P356
P1433
P1476
Spatial sequestration of misfo ...... ellular fitness during stress.
@en
P2093
Stéphanie Escusa-Toret
Willianne I M Vonk
P2860
P2888
P304
P356
10.1038/NCB2838
P577
2013-09-15T00:00:00Z
P5875
P6179
1052062116