eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
about
Pharmacological brake-release of mRNA translation enhances cognitive memoryCrystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodificationC/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase geneSuppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibitionGenome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2pβ-Adrenergic receptor signaling and modulation of long-term potentiation in the mammalian hippocampusThe roles of protein expression in synaptic plasticity and memory consolidationRemote control of gene function by local translationGenes and signaling pathways involved in memory enhancement in mutant miceDefects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutantsSpecific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memoryProteolysis of proBDNF is a key regulator in the formation of memoryeIF5 has GDI activity necessary for translational control by eIF2 phosphorylationeIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memoryRegulation of translation initiation in eukaryotes: mechanisms and biological targetsThe rates of protein synthesis and degradation account for the differential response of neurons to spaced and massed training protocolsMyosin Va associates with mRNA in ribonucleoprotein particles present in myelinated peripheral axons and in the central nervous systemBrain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neuronsIMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowthTranslational control of auditory imprinting and structural plasticity by eIF2α.Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory.Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory FormationPost-training dephosphorylation of eEF-2 promotes protein synthesis for memory consolidation.Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in progression of HIV-associated neurocognitive disorder.Transfer RNA and human diseaseFrom mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis.Aberrant plasticity of peripheral sensory axons in a painful neuropathyShort- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation proteinPERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.Rapamycin for treating Tuberous sclerosis and Autism spectrum disordersControl of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis.Protein phosphatase-dependent circadian regulation of intermediate-term associative memory.A versatile method for cell-specific profiling of translated mRNAs in Drosophila.Upregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4.
P2860
Q21128794-E39E2069-C5D9-40E6-B83E-46828DA8441CQ24296431-DBABAC86-32C7-4A37-B98B-AE7530D5609AQ24336614-09E57900-6F54-45CA-AA7C-E564A647D95CQ24622825-148C2BEA-60B7-447E-9E72-77F362E8F81DQ24657415-8950604F-6BB4-454C-B8D5-A39CB6D6A43CQ26796701-E609D2B4-77AA-488F-8EA5-0F616D16EB55Q26825627-4833D615-2875-4DC4-AED7-99D44A0E769EQ26995087-0AAD7B48-94CB-4166-88C5-896449911A66Q27009274-932D956F-07C5-4AE7-A40D-010F393CDBD8Q27312120-A7461F6B-4D99-425B-AFD9-A1D22400331EQ27320825-40393A65-0224-4152-971A-006A4E94B811Q27438179-71459A92-EDA6-4FEB-B284-77A985F2CE31Q27931061-A91BC952-3C8C-4044-80C0-26E4EA2C415FQ27937122-EB5FB047-817F-45D3-94B5-F3F6EB8A8DB4Q28081526-B735F537-D0AA-4B52-B267-88E22F641185Q28111696-559F09AE-2AEC-46A8-B7F5-8D6F86160B2FQ28478627-96F825D5-AE36-4C3E-BF54-F8B0ED764D75Q28583212-718A1A47-DE5E-4717-9378-8F1EF831E571Q28583609-4E9A5588-A91B-4ED5-B994-3E4B5A98D4C1Q28594198-F91CB9E2-EA37-4931-B78E-1C4DEFCE67EDQ30365036-614E7842-7D54-4B9F-A962-A3E602B87FDEQ30429927-0636FDC1-D0F2-4FDF-8D65-6CDBD9BA9E13Q30465575-95168A7D-F1E0-46AB-8BC2-5D861545E74DQ30476440-C26DAC35-F237-4C1A-AED3-8222FCAB0363Q30486959-1681599B-67C5-4E79-8566-128ECCA6BEFDQ30493570-37E266AF-65BD-416F-A571-576F84CF14B7Q30543820-9097FDC5-7706-4EC7-A5E1-F8432BDDDC7BQ30706228-DA422DA3-2932-4954-A6AA-4982440EF3CCQ33510138-91D82CDB-C773-41B5-A209-6C961D2F4CCAQ33694166-ADA2FA7C-2E51-48AC-B9B6-3973DCCFD169Q33703946-CF7A0597-F4BB-4C08-821E-96E561E4F75DQ33750454-166A8EE0-79B3-4B63-92DF-0C2B18C8AFE4Q33794063-5210770C-D9E9-4AC6-9326-7799710310F0Q33891889-4A7DBD2B-AEBE-49DF-8664-461A089C3D6AQ34024468-4B9465D6-F9F4-4253-B7BD-18625CB4D164Q34024856-D012F4D6-1C16-4300-87E6-281C404AC9A1Q34236497-8C41476D-69D1-4B6E-89CC-084AF9C002F3Q34331443-188E2060-D743-4B05-A48F-367047B44F1DQ34336075-C2D88264-67D5-4829-8C2B-C93ECFB67783Q34358144-FD594659-70C9-4E1B-B53B-ABA95EEBEE81
P2860
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.
@ast
eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.
@en
type
label
eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.
@ast
eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.
@en
prefLabel
eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.
@ast
eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.
@en
P2093
P2860
P1433
P1476
eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.
@en
P2093
Claudio Cuello
Delphine Gobert
Elad Stern
Jean-Claude Lacaille
Jerry Pelletier
Karim Nader
Karine Gamache
Kobi Rosenblum
Kresimir Krnjević
Mauro Costa-Mattioli
P2860
P304
P356
10.1016/J.CELL.2007.01.050
P407
P577
2007-04-01T00:00:00Z