Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. - Wikidata - awgldk - TriplyDB

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.

http://www.wikidata.org/entity/Q30476440

about

Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment Consolidation and translation regulation Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment AMPA receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala.mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels.Rapamycin extends life and health in C57BL/6 mice Insulin action in brain regulates systemic metabolism and brain function.Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy.Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition NMDA mediated contextual conditioning changes miRNA expression mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons.Insulin resistance in Alzheimer's disease.Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgene Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction.Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway.TORC2: a novel target for treating age-associated memory impairment Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus.Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation.Rapamycin has age-, treatment paradigm-, and model-specific anticonvulsant effects and modulates neuropeptide Y expression in rats.Translational control in synaptic plasticity and cognitive dysfunction Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies Rapamycin prevents acute dendritic injury following seizures.Learning and reconsolidation implicate different synaptic mechanisms.Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain.Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse.Reduced protein synthesis in schizophrenia patient-derived olfactory cells.Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: role of autophagy Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery.Mammalian target of rapamycin (mTOR) pathways in neurological diseases.Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling.Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation.

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P2860

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.

http://www.wikidata.org/entity/Q30476440

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Selective pharmacogenetic inhi ...... plasticity and memory storage.

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Selective pharmacogenetic inhi ...... plasticity and memory storage.

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type

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Selective pharmacogenetic inhi ...... plasticity and memory storage.

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Selective pharmacogenetic inhi ...... plasticity and memory storage.

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Selective pharmacogenetic inhi ...... plasticity and memory storage.

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Selective pharmacogenetic inhi ...... plasticity and memory storage.

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Proceedings of the National Academy of Sciences of the United States of America

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Selective pharmacogenetic inhi ...... plasticity and memory storage.

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P2093

Hongyi Zhou

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Loredana Stoica

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Mauro Costa-Mattioli

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Ping Jun Zhu

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Sara C Kozma

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Wei Huang

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

Lessons on longevity from budding yeast

mTOR signaling: at the crossroads of plasticity, memory and disease

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

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3791-3796

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108

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21307309

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3048125

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