Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.
about
Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 proteinMembrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorptionRequirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surfaceOxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cellsFlotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.Ebola virus entry requires the host-programmed recognition of an intracellular receptorCUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegansFomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibeThe target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8)Decreased NPC1L1 expression in the liver from Chinese female gallstone patientsGenetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.NPC1L1 and cholesterol transportDietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1.ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis.Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis.Mechanisms of liver injury relevant to pediatric hepatology.HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver.Phytosterols and phytosterolemia: gene-diet interactionsMutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defectsGenetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels.Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liverEzetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic Fatty liver diseaseProtein mediators of sterol transport across intestinal brush border membrane.Recent advances in small bowel diseases: Part II.Transcriptional regulation of Niemann-Pick C1-like 1 gene by liver receptor homolog-1.Mechanisms for cellular cholesterol transport: defects and human disease.Emerging roles of the intestine in control of cholesterol metabolism.Ezetimibe: an update on the mechanism of action, pharmacokinetics and recent clinical trials.Effect of ezetimibe on plasma cholesterol levels, cholesterol absorption, and secretion of biliary cholesterol in laboratory opossums with high and low responses to dietary cholesterol.Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent.Absorption of vitamin A and carotenoids by the enterocyte: focus on transport proteins.Regulation of bile acid and cholesterol metabolism by PPARsNiemann-Pick C2 (NPC2) and intracellular cholesterol trafficking.Effects of ezetimibe add-on therapy for high-risk patients with dyslipidemia.Transporters as drug targets: discovery and development of NPC1L1 inhibitors.Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport.Cholesterol in Niemann-Pick Type C disease.Sterols and sphingolipids: dynamic duo or partners in crime?Intestinal and hepatic niemann-pick c1-like 1.
P2860
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P2860
Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.
description
2000 nî lūn-bûn
@nan
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
name
Evidence for a Niemann-pick C ...... nd characterization of NPC1L1.
@ast
Evidence for a Niemann-pick C ...... nd characterization of NPC1L1.
@en
type
label
Evidence for a Niemann-pick C ...... nd characterization of NPC1L1.
@ast
Evidence for a Niemann-pick C ...... nd characterization of NPC1L1.
@en
prefLabel
Evidence for a Niemann-pick C ...... nd characterization of NPC1L1.
@ast
Evidence for a Niemann-pick C ...... nd characterization of NPC1L1.
@en
P2093
P356
P1433
P1476
Evidence for a Niemann-pick C ...... nd characterization of NPC1L1.
@en
P2093
P304
P356
10.1006/GENO.2000.6151
P577
2000-04-01T00:00:00Z