The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
about
The structure of the NPC1L1 N-terminal domain in a closed conformationMembrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorptionFlotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.Ezetimibe therapy: mechanism of action and clinical updateMolecular processes that handle -- and mishandle -- dietary lipidsTreatment of dyslipidemia with lovastatin and ezetimibe in an adolescent with cholesterol ester storage disease.Diabetes DyslipidemiaCapitalizing on the autophagic response for treatment of liver disease caused by alpha-1-antitrypsin deficiency and other genetic diseasesHypercholesterolemia induces adipose dysfunction in conditions of obesity and nonobesityMechanisms of Comorbidities Associated With the Metabolic Syndrome: Insights from the JCR:LA-cp Corpulent Rat StrainEbola: translational science considerationsIdentification of novel inhibitors of dietary lipid absorption using zebrafishFatty acid transport protein 4 is dispensable for intestinal lipid absorption in miceSerine palmitoyltransferase (SPT) deficient mice absorb less cholesterolFomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibeCeramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosisLessons from "lower" organisms: what worms, flies, and zebrafish can teach us about human energy metabolism.Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice.Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk.Type of preexisting lipid therapy predicts LDL-C response to ezetimibe.Sitosterolemia: diagnosis, investigation, and management.Both the peroxisome proliferator-activated receptor delta agonist, GW0742, and ezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterolOpposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8)Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.Effects of combined therapy with ezetimibe plus simvastatin after drug-eluting stent implantation in a porcine coronary restenosis model.Structure-based repurposing of FDA-approved drugs as TNF-α inhibitors.An overview of cholesterol managementProprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.NPC1L1 and cholesterol transportDietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1.C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemiaNiemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis.Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice.Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.Influence of ezetimibe on selected parameters of oxidative stress in rat liver subjected to ischemia/reperfusionEfficacy, safety and tolerability of ongoing statin plus ezetimibe versus doubling the ongoing statin dose in hypercholesterolemic Taiwanese patients: an open-label, randomized clinical trialThe enzymes of β-lactam biosynthesis.Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal.Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine
P2860
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P2860
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
description
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2005
@ast
im Juni 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/06/07)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/06/07)
@nl
наукова стаття, опублікована в червні 2005
@uk
name
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@ast
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@en
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@nl
type
label
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@ast
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@en
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@nl
prefLabel
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@ast
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@en
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@nl
P2093
P2860
P3181
P356
P1476
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
@en
P2093
Amanda M Makarewicz
Anthony Ogawa
Brian E Hawes
D Euan Macintyre
Dennis C Dean
Diane E Shevell
Feroze Ujjainwalla
Harry R Davis
Herbert G Bull
James H Crona
P2860
P304
P3181
P356
10.1073/PNAS.0500269102
P407
P577
2005-05-31T00:00:00Z