Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase
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Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode ClassificationSelective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparumCharacterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry.Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment.Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.Drugging tRNA aminoacylation.Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration.The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
P2860
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P2860
Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase
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name
Structural basis for full-spec ...... functions on a tRNA synthetase
@ast
Structural basis for full-spec ...... functions on a tRNA synthetase
@en
type
label
Structural basis for full-spec ...... functions on a tRNA synthetase
@ast
Structural basis for full-spec ...... functions on a tRNA synthetase
@en
prefLabel
Structural basis for full-spec ...... functions on a tRNA synthetase
@ast
Structural basis for full-spec ...... functions on a tRNA synthetase
@en
P2093
P2860
P356
P1476
Structural basis for full-spec ...... functions on a tRNA synthetase
@en
P2093
Adam Mirando
Christopher S Francklyn
Kaige Chen
Seung Jae Jeong
Sunghoon Kim
P2860
P2888
P356
10.1038/NCOMMS7402
P407
P50
P577
2015-03-31T00:00:00Z
P5875
P6179
1048801637