ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
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Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetasesEvolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode ClassificationStructures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sicknessAntimalarial drug discovery - approaches and progress towards new medicines.Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetaseA genomic and evolutionary approach reveals non-genetic drug resistance in malariaBiochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetaseSelective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparumAssembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology DomainsStructural basis for full-spectrum inhibition of translational functions on a tRNA synthetaseConformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines.The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation CodonsHalofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone.Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.Emergence and evolution.Halofuginone for fibrosis, regeneration and cancer in the gastrointestinal tract.Halofuginone - the multifaceted molecule.Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.The Aminoacyl-tRNA Synthetase Complex.Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity.A novel autoregulatory loop between the Gcn2-Atf4 pathway and (L)-Proline [corrected] metabolism controls stem cell identity.The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment.Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy.Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.Drugging tRNA aminoacylation.Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration.Effervescent-salt-assisted dispersive micro-solid-phase extraction using mesoporous hybrid materials coupled with ultra-performance liquid chromatography for the determination of trace-level compounds in complicated plant preparations.Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains.
P2860
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P2860
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@ast
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@en
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@nl
type
label
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@ast
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@en
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@nl
prefLabel
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@ast
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@en
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@nl
P2093
P2860
P3181
P356
P1433
P1476
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
@en
P2093
Paul Schimmel
Xiang-Lei Yang
P2860
P2888
P3181
P356
10.1038/NATURE11774
P407
P50
P577
2013-02-07T00:00:00Z
P5875
P6179
1036948204