Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide.
about
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificitiesGenetic spell-checking: gene editing using single-stranded DNA oligonucleotidesOligo/polynucleotide-based gene modification: strategies and therapeutic potentialTriplex-induced recombination in human cell-free extracts. Dependence on XPA and HsRad51.Triple-helix formation induces recombination in mammalian cells via a nucleotide excision repair-dependent pathway.Site-directed recombination via bifunctional PNA-DNA conjugates.Oligonucleotides and derivatives as gene-specific control agents.Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair.Targeted correction of a thalassemia-associated beta-globin mutation induced by pseudo-complementary peptide nucleic acidsImproved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases.Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotidesAlleviating transcript insufficiency caused by Friedreich's ataxia triplet repeatsTargeting and processing of site-specific DNA interstrand crosslinks.The potential of nucleic acid repair in functional genomics.Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells.Triplex-forming molecules: from concepts to applications.Gene repair in the new age of gene therapy.Stimulation of D-loop formation by polypurine/polypyrimidine sequencesThe potential for gene repair via triple helix formation.Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes.Local delivery of gene-modifying triplex-forming molecules to the epidermis.Processing of triplex-directed psoralen DNA interstrand crosslinks by recombination mechanisms.Molecular recognition via triplex formation of mixed purine/pyrimidine DNA sequences using oligoTRIPs.RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine.Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions.Repair of DNA lesions associated with triplex-forming oligonucleotides.Targeted gene conversion induced by triplex-directed psoralen interstrand crosslinks in mammalian cells.Genetic strategies for the treatment of sickle cell anaemia.Targeted gene repair in mammalian cells using chimeric RNA/DNA oligonucleotides and modified single-stranded vectors.A simple model for gene targeting.Chromosome targeting at short polypurine sites by cationic triplex-forming oligonucleotides.Repair of single-point mutations by polypurine reverse Hoogsteen hairpins.The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts.Correction of chromosomal point mutations in human cells with bifunctional oligonucleotides.Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotidesTranscription dependence of chromosomal gene targeting by triplex-forming oligonucleotides.In vivo gene repair of point and frameshift mutations directed by chimeric RNA/DNA oligonucleotides and modified single-stranded oligonucleotides.Branched oligonucleotides induce in vivo gene conversion of a mutated EGFP reporter.Tyrosinase gene correction using fluorescent oligonucleotides.Implications of cell cycle progression on functional sequence correction by short single-stranded DNA oligonucleotides.
P2860
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P2860
Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide.
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Targeted correction of an epis ...... iplex-forming oligonucleotide.
@ast
Targeted correction of an epis ...... iplex-forming oligonucleotide.
@en
type
label
Targeted correction of an epis ...... iplex-forming oligonucleotide.
@ast
Targeted correction of an epis ...... iplex-forming oligonucleotide.
@en
prefLabel
Targeted correction of an epis ...... iplex-forming oligonucleotide.
@ast
Targeted correction of an epis ...... iplex-forming oligonucleotide.
@en
P2093
P2860
P356
P1476
Targeted correction of an epis ...... iplex-forming oligonucleotide.
@en
P2093
P2860
P304
11541-11548
P356
10.1074/JBC.274.17.11541
P407
P577
1999-04-01T00:00:00Z