A porcine homolog of the major secretory protein of human epididymis, HE1, specifically binds cholesterol.
about
NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterolsNPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterolsRegulation of sterol transport between membranes and NPC2Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 diseaseThe LDL receptorRab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cellsCell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C diseaseStructural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 DiseaseStructure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of CholesterolSaccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2.Vasectomy influences expression of HE1 but not HE2 and HE5 genes in human epididymisLoss of Niemann-Pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathwayDemonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift methodNPC2 is expressed in human and murine liver and secreted into bile: potential implications for body cholesterol homeostasisGenetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transportThe integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.Proteins that bind and move lipids: MsbA and NPC1.A neurodegenerative disease affecting synaptic connections in Drosophila mutant for the tumor suppressor morphogen Patched.Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.Comparative genomic analysis of innate immunity reveals novel and conserved components in crustacean food crop species.Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrinModulation of cellular cholesterol transport and homeostasis by Rab11.Therapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease.Niemann-Pick disease type C: spectrum of HE1 mutations and genotype/phenotype correlations in the NPC2 group.Post testicular sperm maturational changes in the bull: important role of the epididymosomes and prostasomes.Sterols in spermatogenesis and sperm maturation.Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation.Lipid rafts: keys to sperm maturation, fertilization, and early embryogenesis.Niemann-Pick Type C-2 Disease: Identification by Analysis of Plasma Cholestane-3β,5α,6β-Triol and Further Insight into the Clinical Phenotype.Non-vesicular sterol transport in cells.Proteomic analysis of mouse models of Niemann-Pick C disease reveals alterations in the steady-state levels of lysosomal proteins within the brain.Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis.Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking.Comparative structural modeling and inference of conserved protein classes in Drosophila seminal fluid.Cholesterol in Niemann-Pick Type C disease.Lysosomal proteomics and disease.Endosomal cholesterol trafficking: protein factors at a glance.Current controversies in Niemann-Pick C1 disease: steroids or gangliosides; neurons or neurons and glia.Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop.
P2860
Q24300768-52AD5BC9-65A5-4141-B491-F1EC75F0DD24Q24305499-3228BF87-AA7C-4B7A-93B6-3415BC3500DEQ24316973-3CF686CE-2402-4BE3-BCFC-8CADD16A7B49Q24554202-5408C120-14AE-4034-A822-DCB1C6B4EC0BQ24658039-D3B0654C-1776-4422-9836-44DAE27DE86DQ24676084-96A75E6F-7A7B-4F8A-9A20-E0D59DC60E7FQ24811579-72DD0AD2-A204-4241-9195-7FD00B76882EQ27645956-076EB127-B066-4DE8-AC24-37C8503BEA27Q27646366-460B09D8-B017-4345-91B0-E31188FE7316Q27937861-5541890E-1D82-40E8-BAA0-6556AD4439F8Q28190078-34AE34A3-EC00-4942-A3D4-CAC327AC5060Q28476678-8D3BBC8E-109D-4504-9676-C2BDF2733F33Q28589614-D44AAB95-8BC3-4BDC-8C15-1F805ED67348Q28590002-73CEAC0D-F3F8-45C6-A8D8-46533BFCA141Q28594812-FFE31BAC-3C39-4808-AB0A-A316B97D108DQ30332511-A2CF0935-EC3C-4D53-B8F4-1D619084CCB7Q30409962-9750321E-3D5F-4383-AC83-C2CDBD86D5C9Q30490885-9375DCD9-9886-4269-BF32-947105B9FFCAQ33227195-7EB18690-D878-4320-BFB0-FA351E2B9448Q33705255-1F1EDBC4-5E33-49BB-AD0E-495AAFB92F78Q33705848-AE9FF316-BB3D-48B3-8C94-993A224F11A6Q33945068-3D194524-E172-444E-8A23-41714B73816FQ34060766-73C64D83-2829-4B13-A1F8-21F73E58EE0EQ34069183-4812DFD1-4CED-4C55-9D85-DDC5C6233370Q34112998-C909D209-67F7-47FF-B7BE-1563AF9F8CC7Q34218896-C7B56553-A739-4C8A-B134-6D90F8BF2924Q34307905-EF7EEB1E-BC2D-4BCC-9D90-34B9CC337EBEQ34503198-7F080D82-155C-4B6C-AFCF-ECE63D3889B4Q34745673-CB44A192-AFD3-4C9D-8CDD-AEA4D340EBB6Q35795421-A693808E-E80E-4217-B7AB-467A5BE7CD84Q36145366-03F90407-E695-4DF8-9AEE-93B1595D3ADEQ36837310-F804A59F-23D8-49CD-A83A-3528516E8B80Q37099675-E9C7D9F3-F780-4AD5-8F00-6C4CBF25850DQ37397806-A69E1E17-4C58-4C5F-B63D-2D7FC9A74812Q37533771-32C7DE0C-C0D7-4ADE-90CF-18117D1C6614Q37705138-F4D98EAF-0E57-438F-90F6-2A6F48717A11Q37817158-AB341601-F5F5-48EC-8070-2E6BEB45CF64Q38061067-6AA44B7B-48A0-413A-A3F5-6B09CC6560E8Q38071990-4579E594-28EA-4EB5-A678-90B814E79778Q38296620-47164836-51F0-4A53-9C2F-E06B988E2A52
P2860
A porcine homolog of the major secretory protein of human epididymis, HE1, specifically binds cholesterol.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A porcine homolog of the major ...... pecifically binds cholesterol.
@ast
A porcine homolog of the major ...... pecifically binds cholesterol.
@en
type
label
A porcine homolog of the major ...... pecifically binds cholesterol.
@ast
A porcine homolog of the major ...... pecifically binds cholesterol.
@en
prefLabel
A porcine homolog of the major ...... pecifically binds cholesterol.
@ast
A porcine homolog of the major ...... pecifically binds cholesterol.
@en
P2093
P1476
A porcine homolog of the major ...... pecifically binds cholesterol.
@en
P2093
J L Dacheux
S Hiramoto
P304
P356
10.1016/S1388-1981(99)00070-0
P407
P577
1999-06-01T00:00:00Z