Peripheral metabotropic glutamate receptors as drug targets for pain relief.
about
The glutamatergic system as a target for neuropathic pain reliefASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats.Blockade of glutamate release by botulinum neurotoxin type A in humans: a dermal microdialysis study.Hypo-anxious phenotype of adolescent offspring prenatally exposed to LPS is associated with reduced mGluR5 expression in hippocampus.Enhanced group II mGluR-mediated inhibition of pain-related synaptic plasticity in the amygdala.Nerve demyelination increases metabotropic glutamate receptor subtype 5 expression in peripheral painful mononeuropathy.Group II mGluRs modulate baseline and arthritis pain-related synaptic transmission in the rat medial prefrontal cortex.Novel Scaffold Identification of mGlu1 Receptor Negative Allosteric Modulators Using a Hierarchical Virtual Screening Approach.Therapeutic potential of metabotropic glutamate receptor modulators.Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain.mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.Current approaches with the glutamatergic system as targets in the treatment of neuropathic pain.Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.Supraspinal metabotropic glutamate receptors: a target for pain relief and beyond.Nociceptive primary afferents: they have a mind of their own.Group II mGluRs suppress hyperexcitability in mouse and human nociceptors.Loss of long-term depression in the insular cortex after tail amputation in adult mice.Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors.Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons.Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones.Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain.
P2860
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P2860
Peripheral metabotropic glutamate receptors as drug targets for pain relief.
description
2002 nî lūn-bûn
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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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name
Peripheral metabotropic glutamate receptors as drug targets for pain relief.
@ast
Peripheral metabotropic glutamate receptors as drug targets for pain relief.
@en
type
label
Peripheral metabotropic glutamate receptors as drug targets for pain relief.
@ast
Peripheral metabotropic glutamate receptors as drug targets for pain relief.
@en
prefLabel
Peripheral metabotropic glutamate receptors as drug targets for pain relief.
@ast
Peripheral metabotropic glutamate receptors as drug targets for pain relief.
@en
P2860
P356
P1476
Peripheral metabotropic glutamate receptors as drug targets for pain relief.
@en
P2093
Susan M Carlton
Volker Neugebauer
P2860
P304
P356
10.1517/14728222.6.3.349
P407
P577
2002-06-01T00:00:00Z