The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.
about
Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMPOrganic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin GIn vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cellsOATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamiliesRenal drug transporters and their significance in drug-drug interactionsActivation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transportPermeation of fluorophore-conjugated phalloidin into live hair cells of the inner ear is modulated by P2Y receptors.Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacinTransport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20)Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Tenofovir renal proximal tubular toxicity is regulated by OAT1 and MRP4 transportersImportance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.Renal handling of amphotericin B and amphotericin B-deoxycholate and potential renal drug-drug interactions with selected antivirals.Transmembrane peptide as potent inhibitor of oligomerization and function of human organic anion transporter 1.Impact of a tenofovir disoproxil fumarate plus ritonavir-boosted protease inhibitor-based regimen on renal function in HIV-infected individuals: a prospective, multicenter study.Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets.Molecular mechanism of ochratoxin a transport in the kidney.Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity.Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections.The flounder organic anion transporter fOat has sequence, function, and substrate specificity similarity to both mammalian Oat1 and Oat3.First pharmacokinetic and safety study in humans of the novel lipid antiviral conjugate CMX001, a broad-spectrum oral drug active against double-stranded DNA viruses.Evaluation of chinese-herbal-medicine-induced herb-drug interactions: focusing on organic anion transporter 1.Development and characterization of immobilized human organic anion transporter-based liquid chromatographic stationary phase: hOAT1 and hOAT2.Endocrine and metabolic regulation of renal drug transporters.Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B.Renal organic anion transporters (SLC22 family): expression, regulation, roles in toxicity, and impact on injury and disease.What do drug transporters really do?A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity.Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discriminationSex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys.Pharmacokinetics of low-dose cidofovir in kidney transplant recipients with BK virus infection.Antioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kützing extract in experimental type 2 diabetic rats.Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathwayThe human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.Regulation of human organic anion transporter 1 by ANG II: involvement of protein kinase Calpha.Novobiocin is a potent inhibitor for human organic anion transporters.Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis.Brincidofovir Is Not a Substrate for the Human Organic Anion Transporter 1: A Mechanistic Explanation for the Lack of Nephrotoxicity Observed in Clinical Studies
P2860
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P2860
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The antiviral nucleotide analo ...... l organic anion transporter 1.
@ast
The antiviral nucleotide analo ...... l organic anion transporter 1.
@en
type
label
The antiviral nucleotide analo ...... l organic anion transporter 1.
@ast
The antiviral nucleotide analo ...... l organic anion transporter 1.
@en
prefLabel
The antiviral nucleotide analo ...... l organic anion transporter 1.
@ast
The antiviral nucleotide analo ...... l organic anion transporter 1.
@en
P2093
P1476
The antiviral nucleotide analo ...... l organic anion transporter 1.
@en
P2093
P304
P577
1999-09-01T00:00:00Z