The herpesvirus proteases as targets for antiviral chemotherapy.
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Current and potential treatments for ubiquitous but neglected herpesvirus infectionsVirus maturation: dynamics and mechanism of a stabilizing structural transition that leads to infectivity.Broad-Spectrum Allosteric Inhibition of Herpesvirus ProteasesDimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine ProteaseNovel agents and strategies to treat herpes simplex virus infections.Agents and strategies in development for improved management of herpes simplex virus infection and disease.Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.Inhibition of a viral enzyme by a small-molecule dimer disruptor.Allosteric regulation of protease activity by small molecules.1-Phenyl-1H-naphtho-[1,2-e][1,3]oxazin-3(2H)-one.Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions.Identification of a varicella-zoster virus replication inhibitor that blocks capsid assembly by interacting with the floor domain of the major capsid protein.A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.Non-nucleoside inhibitors of herpesviruses.High-performance liquid chromatographic enantioseparation of Betti base analogs on a newly developed isopropyl carbamate-cyclofructan6-based chiral stationary phaseSoluble expression, purification, and characterization of active recombinant human tissue plasminogen activator by auto-induction in E. coliEnzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain.Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric ProteaseDesign of translactam HCMV protease inhibitors as potent antivirals.Inhibitors of SARS-3CLpro: virtual screening, biological evaluation, and molecular dynamics simulation studies.Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a.Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.Computational Studies of Benzoxazinone Derivatives as Antiviral Agents against Herpes Virus Type 1 Protease.Proteolytic activity assayed by subcellular localization switching of a substrate.Sequential autoprocessing of Marek's disease herpesvirus protease differs from that of other herpesvirusesAn antiviral principle present in a purified fraction from Melia azedarach L. leaf aqueous extract restrains herpes simplex virus type 1 propagation.CeCl₃.7H2O/NaI-promoted direct synthesis of 1,3-benzoxazine-2-thione n-nucleosides under microwave irradiation.Strategies in the Design of Antiviral Drugs
P2860
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P2860
The herpesvirus proteases as targets for antiviral chemotherapy.
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
@wuu
name
The herpesvirus proteases as targets for antiviral chemotherapy.
@ast
The herpesvirus proteases as targets for antiviral chemotherapy.
@en
type
label
The herpesvirus proteases as targets for antiviral chemotherapy.
@ast
The herpesvirus proteases as targets for antiviral chemotherapy.
@en
prefLabel
The herpesvirus proteases as targets for antiviral chemotherapy.
@ast
The herpesvirus proteases as targets for antiviral chemotherapy.
@en
P2860
P1476
The herpesvirus proteases as targets for antiviral chemotherapy.
@en
P2093
P2860
P356
10.1177/095632020001100101
P577
2000-01-01T00:00:00Z