Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions.
about
Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity.The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain.Nuclear localization sequences in cytomegalovirus capsid assembly proteins (UL80 proteins) are required for virus production: inactivating NLS1, NLS2, or both affects replication to strikingly different extents.Recovery of an HMWP/hmwBP (pUL48/pUL47) complex from virions of human cytomegalovirus: subunit interactions, oligomer composition, and deubiquitylase activity.Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a.The amino-conserved domain of human cytomegalovirus UL80a proteins is required for key interactions during early stages of capsid formation and virus productionCytomegalovirus capsid protease: biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin)
P2860
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P2860
Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Cytomegalovirus assemblin (pUL ...... roteinase absent from virions.
@ast
Cytomegalovirus assemblin (pUL ...... roteinase absent from virions.
@en
Cytomegalovirus assemblin
@nl
type
label
Cytomegalovirus assemblin (pUL ...... roteinase absent from virions.
@ast
Cytomegalovirus assemblin (pUL ...... roteinase absent from virions.
@en
Cytomegalovirus assemblin
@nl
prefLabel
Cytomegalovirus assemblin (pUL ...... roteinase absent from virions.
@ast
Cytomegalovirus assemblin (pUL ...... roteinase absent from virions.
@en
Cytomegalovirus assemblin
@nl
P2093
P2860
P1433
P1476
Cytomegalovirus assemblin (pUL ...... roteinase absent from virions.
@en
P2093
Chee-Kai Chan
Edward J Brignole
Wade Gibson
P2860
P304
P356
10.1128/JVI.76.17.8667-8674.2002
P407
P577
2002-09-01T00:00:00Z