Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir.

Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir.

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http://www.wikidata.org/entity/Q30891342

Q30891342

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Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches Advances in structure elucidation of small molecules using mass spectrometry Analytical tools and approaches for metabolite identification in early drug discovery.Data acquisition and data mining techniques for metabolite identification using LC coupled to high-resolution MS.Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data.Screening for DNA adducts by data-dependent constant neutral loss-triple stage mass spectrometry with a linear quadrupole ion trap mass spectrometer High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites.Combined computational metabolite prediction and automated structure-based analysis of mass spectrometric data.Data-dependent neutral gain MS3: toward automated identification of the N-oxide functional group in drug metabolites.Exposure Marker Discovery of Phthalates Using Mass Spectrometry.Current use of high-resolution mass spectrometry in drug screening relevant to clinical and forensic toxicology and doping control.Mass spectrometry-based metabolomics, analysis of metabolite-protein interactions, and imaging.Identification of the metabolites of gigantol in rat urine by ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.Identification of xenobiotic metabolites from biological fluids using flow injection analysis high-resolution mass spectrometry and post-acquisition data filtering.Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D(1) and antagonist at D(2) receptors, in rats.From known knowns to known unknowns: predicting in vivo drug metabolites.Drug metabolite profiling and identification by high-resolution mass spectrometry.Software automation tools for increased throughput metabolic soft-spot identification in early drug discovery.Applications of mass spectrometry in drug metabolism: 50 years of progress.Recent developments in software tools for high-throughput in vitro ADME support with high-resolution MS.Cells on pores: a simulation-driven analysis of transcellular small molecule transport.Physicochemical characteristics of structurally determined metabolite-protein and drug-protein binding events with respect to binding specificity.Metabolite profiling of praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple quadrupole linear ion trap mass spectrometer.The determination of flavonoids in Wikstroemia indica C. A. Mey. by liquid chromatography with photo-diode array detection and negative electrospray ionization tandem mass spectrometry.Structural characterization of sulfadiazine metabolites using H/D exchange combined with various MS/MS experiments.Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate.Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3 Quantitative monitoring of tamoxifen in human plasma extended to 40 metabolites using liquid-chromatography high-resolution mass spectrometry: new investigation capabilities for clinical pharmacology

P2860

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P2860

Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir.

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http://www.wikidata.org/entity/Q30891342

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2004 nî lūn-bûn

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2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2004 թվականի փետրվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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