Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2.
about
The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretionIdentification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates.Phosphoinositides: tiny lipids with giant impact on cell regulationThe Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton.Screening assay for small-molecule inhibitors of synaptojanin 1, a synaptic phosphoinositide phosphatase.Phosphoinositide phosphatases in cell biology and disease.Massive calcium-activated endocytosis without involvement of classical endocytic proteinsThe host phosphoinositide 5-phosphatase SHIP2 regulates dissemination of vaccinia virusThe structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis.Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.Inositol lipid phosphatases in membrane trafficking and human disease.Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.Phosphatidylinositolphosphate phosphatase activities and cancer.SHIP2: Structure, Function and Inhibition.Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2.Structural basis for interdomain communication in SHIP2 providing high phosphatase activity.On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate.I(1;3;4;5)P4 is dephosphorylated to I(1;3;4)P3 by INPP5[3]/ITPK1 in the cytosolInpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling.
P2860
Q24634647-94945E05-DA1F-4C69-99CA-8224376EA7F8Q25255706-8A30C790-C6A7-46EF-B69B-9E94BC351FE2Q27012953-A856FD08-9DEE-4F4E-8377-641E8C3D36ABQ30160351-5B4B572E-1BED-409F-86A9-A94FD4BF6CA6Q33561690-39840A07-2E8C-4D1A-BDB7-540EB3446B22Q33862413-A40C2371-6B36-4EA3-ADF0-172E5E7A3678Q34156716-694B4019-183F-485A-8AA8-6B21E54F8AC0Q35077647-A51C59E5-A123-4EF9-B633-42CF5CA999EFQ35225936-4C1C77E8-F328-4F65-8061-B85CD3B10FBAQ37989699-DB7751CE-9AD1-473A-AE97-CD9B25BCF839Q38223317-29C81240-1600-4B52-95EE-381EA6B9ACBFQ38409013-12A427DF-B43A-4F70-90C1-32BFD7E18EB2Q38572786-FED15D91-2E97-461E-80A2-F06756E26A63Q38788518-12043A1B-EAB6-4B79-8BBD-6AE7F4403E0FQ38898071-E551DFD0-CE45-44AA-8ABE-835267F213E8Q39810450-13E4110E-A75C-4AC4-BE0C-9AC2BD9AE9C5Q41329955-D6CCB3E0-B365-4933-8A8E-605C44A3B2F5Q46867331-A902799D-FDA3-4EEF-895B-FCA7E55337D3Q50293342-56D083B9-0818-433E-8002-6494F402981BQ50481460-C2AA0BA6-EBCA-4C28-A444-D6428AF6367D
P2860
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2.
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Comparative mechanistic and su ...... pombe Synaptojanin and SHIP2.
@ast
Comparative mechanistic and su ...... pombe Synaptojanin and SHIP2.
@en
type
label
Comparative mechanistic and su ...... pombe Synaptojanin and SHIP2.
@ast
Comparative mechanistic and su ...... pombe Synaptojanin and SHIP2.
@en
prefLabel
Comparative mechanistic and su ...... pombe Synaptojanin and SHIP2.
@ast
Comparative mechanistic and su ...... pombe Synaptojanin and SHIP2.
@en
P2093
P2860
P921
P356
P1476
Comparative mechanistic and su ...... pombe Synaptojanin and SHIP2.
@en
P2093
James H Hurley
Sung-Kee Chung
Wei-Qing Wang
Yong-Uk Kwon
Yosuke Tsujishita
Young-Hoon Ahn
Yuling Chi
Zhong-Yin Zhang
P2860
P304
44987-44995
P356
10.1074/JBC.M406416200
P407
P577
2004-08-16T00:00:00Z