The lipid phosphatase SHIP2 controls insulin sensitivity
about
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivoIdentification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation.Increased insulin action in SKIP heterozygous knockout miceSOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationThe SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actinA steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocationAntidiabetic properties of dietary flavonoids: a cellular mechanism reviewInsulin receptor signaling in normal and insulin-resistant statesPI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasmsThe mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseasesPhosphoinositides: tiny lipids with giant impact on cell regulationPhosphoinositides: Key modulators of energy metabolismEvidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunctionNMR Studies of a Heterotypic Sam−Sam Domain Association: The Interaction between the Lipid Phosphatase Ship2 and the EphA2 Receptor † , ‡The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cellsSHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signalingThe inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting systemSHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclastsInositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte developmentThe inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesityMolecular mechanism and physiological functions of clathrin-mediated endocytosisSHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties.SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.Novel phosphotyrosine targets of FGFR2IIIb signaling.Whole-genome analysis reveals that mutations in inositol polyphosphate phosphatase-like 1 cause opsismodysplasia.A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart.Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2.Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissueMuscle-specific Pten deletion protects against insulin resistance and diabetesPI(3,4)P2 plays critical roles in the regulation of focal adhesion dynamics of MDA-MB-231 breast cancer cellsBiofluid lipidome: a source for potential diagnostic biomarkers.Phosphoinositide phosphatases in cell biology and disease.The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication.Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice.Acute insulin resistance following injury.Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- miceSHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo.Molecular mechanisms of insulin resistance.
P2860
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P2860
The lipid phosphatase SHIP2 controls insulin sensitivity
description
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2001
@ast
scientific journal article
@en
vedecký článok (publikovaný 2001/01/04)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/01/04)
@nl
наукова стаття, опублікована в січні 2001
@uk
مقالة علمية (نشرت في 4-1-2001)
@ar
name
The lipid phosphatase SHIP2 controls insulin sensitivity
@ast
The lipid phosphatase SHIP2 controls insulin sensitivity
@en
The lipid phosphatase SHIP2 controls insulin sensitivity
@nl
type
label
The lipid phosphatase SHIP2 controls insulin sensitivity
@ast
The lipid phosphatase SHIP2 controls insulin sensitivity
@en
The lipid phosphatase SHIP2 controls insulin sensitivity
@nl
prefLabel
The lipid phosphatase SHIP2 controls insulin sensitivity
@ast
The lipid phosphatase SHIP2 controls insulin sensitivity
@en
The lipid phosphatase SHIP2 controls insulin sensitivity
@nl
P2093
P356
P1433
P1476
The lipid phosphatase SHIP2 controls insulin sensitivity
@en
P2093
F. Desmedt
J. Behrends
J. E. Dumont
J. F. Tanti
M. Doherty
S. Clément
S. Schurmans
P2888
P356
10.1038/35051094
P407
P577
2001-01-04T00:00:00Z
P6179
1037173820