The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways. - Wikidata - awgldk - TriplyDB

The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.

The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.

http://www.wikidata.org/entity/Q30989694

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Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain G Protein-Coupled Receptors in Cancer CUX1 transcription factor is a downstream effector of the proteinase-activated receptor 2 (PAR2)Identification of potential small molecule binding pockets on Rho family GTPases Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61.Binding of the WASP/N-WASP-interacting protein WIP to actin regulates focal adhesion assembly and adhesion Zyxin is involved in thrombin signaling via interaction with PAR-1 receptor The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways.Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models.Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis.Targeting protease-activated receptor-1 with cell-penetrating pepducins in lung cancer.Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells.The effect of therapeutic anticoagulation on overall survival in men receiving first-line docetaxel chemotherapy for metastatic castration-resistant prostate cancer.Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma.Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells G-protein signaling: back to the future Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase Cϵ Protease-activated receptors (PARs)--biology and role in cancer invasion and metastasis.Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice.Epigenetically silenced GNG4 inhibits SDF1α/CXCR4 signaling in mesenchymal glioblastoma Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222 G protein-coupled receptors go extracellular: RhoA integrates the integrins.Regulation and physiological functions of G12/13-mediated signaling pathways.A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis.Role of G12 proteins in oncogenesis and metastasis Signaling mechanisms that regulate smooth muscle cell differentiation.Rho GTPases modulate malignant transformation of tumor cells.Platelet-targeted pharmacologic treatments as anti-cancer therapy.Thrombin-unique coagulation system protein with multifaceted impacts on cancer and metastasis.Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia.Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs).Opportunities for therapeutic antibodies directed at G-protein-coupled receptors.Differential effects of serine proteases on the migration of normal and tumor cells: implications for tumor microenvironment.A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.Thrombin induces nitric-oxide synthase via Galpha12/13-coupled protein kinase C-dependent I-kappaBalpha phosphorylation and JNK-mediated I-kappaBalpha degradation.

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The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.

http://www.wikidata.org/entity/Q30989694

description

2001 nî lūn-bûn

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2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2001 թվականի ապրիլին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年论文

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The thrombin receptor, PAR-1, ...... o-mediated signaling pathways.

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The thrombin receptor, PAR-1, ...... o-mediated signaling pathways.

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The thrombin receptor, PAR-1, ...... o-mediated signaling pathways.

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The thrombin receptor, PAR-1, ...... o-mediated signaling pathways.

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The thrombin receptor, PAR-1, ...... o-mediated signaling pathways.

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Kay RJ

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P2860

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes

Thrombin receptor overexpression in malignant and physiological invasion processes

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

CDC42 and FGD1 cause distinct signaling and transforming activities.

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity

Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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