β-actin and γ-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. - Wikidata - awgldk - TriplyDB

β-actin and γ-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance.

β-actin and γ-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance.

http://www.wikidata.org/entity/Q30990855

about

Multiphasic analysis of whole exome sequencing data identifies a novel mutation of ACTG1 in a nonsyndromic hearing loss family Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia Conditional gene expression in the mouse inner ear using Cre-loxP.Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levels Evidence for changes in beta- and gamma-actin proportions during inner ear hair cell life Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development Restricted morphological and behavioral abnormalities following ablation of β-actin in the brain Developmental regulation of planar cell polarity and hair-bundle morphogenesis in auditory hair cells: lessons from human and mouse genetics.Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice.Genetics of auditory mechano-electrical transduction.β-Actin and fascin-2 cooperate to maintain stereocilia length.Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea.Actin in hair cells and hearing loss.Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice.Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear.Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins.Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells.Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74 Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss.Quadriceps myopathy caused by skeletal muscle-specific ablation of β(cyto)-actin Axonal regeneration and neuronal function are preserved in motor neurons lacking ß-actin in vivo.Distinct functional interactions between actin isoforms and nonsarcomeric myosins β-Actin specifically controls cell growth, migration, and the G-actin pool Downregulation of β-actin gene and human antigen R in human keratoconus.Nonredundant roles of cytoplasmic β- and γ-actin isoforms in regulation of epithelial apical junctions Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane Disruption of the ATE1 and SLC12A1 Genes by Balanced Translocation in a Boy with Non-Syndromic Hearing Loss.Relative importance of βcyto- and γcyto-actin in primary mouse embryonic fibroblasts.Insights into the effects of disease-causing mutations in human actins.The cuticular plate: a riddle, wrapped in a mystery, inside a hair cell.Stereocilia morphogenesis and maintenance through regulation of actin stability.Baraitser-Winter cerebrofrontofacial syndrome.Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses.Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression.Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms.Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking.Mammalian Actins: Isoform-Specific Functions and Diseases.Molecular mechanisms of disease-related human β-actin mutations p.R183W and p.E364K.Dystonia-deafness syndrome caused by ACTB p.Arg183Trp heterozygosity shows striatal dopaminergic dysfunction and response to pallidal stimulation.

P2860

Q21266678-AA2844B8-5EE4-4C35-B662-C94A67344191 Q24601390-1935B7F3-1DC4-4B7E-93AF-CF207298F7D1 Q26991845-585D1C5A-8532-4D5B-9B15-4243CF69D6C9 Q27309163-DEE31DAA-33C3-4E6C-90FF-ABFD444E03BD Q27336425-6D5F7161-26C0-446E-A199-48B70681EF58 Q27342916-0B48DCF0-5E7A-421E-A82C-DF3D92D353EF Q28731512-A1F50CB5-9091-46E5-BDD7-B9F72658F12B Q30278866-D33A4877-F6DD-4FE5-A919-BB881B425A77 Q30355977-2DBB6D84-73A9-4D16-AD40-11DF1C1871A4 Q30404370-6FA03D17-FA0B-48E9-BAF3-BD8F771D2AE2 Q30421422-9A9EF79F-4E4D-4C45-ACAB-39FEB6116A33 Q30447400-C20816A0-5BB6-44DE-BC3F-D5FB24F64AA8 Q30453489-5F83D811-F09A-4ED8-AF81-D5CAA5B74C27 Q30454015-AFFFC8C9-8D95-4F69-BE0E-259BC80D3AB1 Q30607162-40D40F2D-C794-4F90-B574-F86C68B07FA3 Q30644335-A6EFC53B-E9E4-440E-884F-5392BA1F674A Q30659759-3B59FC90-3C04-4774-B25E-872BCF2D1F2D Q33611079-1220E4EF-C913-4D5A-AE20-EC02B48841CA Q34156544-1D44214E-FA86-4FDE-9376-2700E0116293 Q34527976-012552BE-6796-460B-A469-58A89A24436C Q34625134-BE7DBD58-98D8-4C53-A364-D20867B9D3CF Q34708286-C5BBBB3F-776A-4487-9170-34741E016AE4 Q34907205-9201099F-B785-4C91-ABDF-4F9BF216A835 Q35475014-5601FC8E-BFBE-4206-8375-9DD4DEC747FD Q36223715-10BF83D0-207D-43F7-A155-A611052D865E Q36234461-C5A668B7-15CF-4F6D-9026-5FC5C438360A Q37237312-2411C265-17CE-407D-A742-7D32194C4556 Q37573604-213CCE89-4A51-46AF-A806-94F8E966C393 Q37699020-E3ABC89E-85F7-4E3E-AA3B-CAD91B6DBA5D Q38191504-7D114F98-0183-43CF-B2F4-A9463F368216 Q38536077-ABA454EC-E3D3-4960-B52D-B578AD4B059B Q38938244-5665A60C-908C-45A0-B644-ED7226E8F6F3 Q38953810-28AD28A8-67C3-43DB-82FD-66BD0B13DDEA Q39757117-C686C02A-B643-4369-9E55-93F25DDF41B7 Q44728316-1894BAD0-2CF7-4C78-9BA9-692B8D559F5C Q47266699-7AF1456C-F63F-4E75-9076-F6273FB19312 Q48095910-EA9E7366-220B-47B8-8D63-71461E4003C0 Q49145326-D4CB0F4B-DDDD-4767-A935-B5A7AD988D0D Q50632417-3B16E710-EF4D-4BF3-87B6-D5C761538CB7 Q54983407-C7290D13-5EE8-4505-9CA6-F744A4312D75

P2860

β-actin and γ-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance.

http://www.wikidata.org/entity/Q30990855

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

β-actin and γ-actin are each d ...... d for Stereocilia maintenance.

@ast

β-actin and γ-actin are each d ...... d for Stereocilia maintenance.

@en

type

label

β-actin and γ-actin are each d ...... d for Stereocilia maintenance.

@ast

β-actin and γ-actin are each d ...... d for Stereocilia maintenance.

@en

prefLabel

β-actin and γ-actin are each d ...... d for Stereocilia maintenance.

@ast

β-actin and γ-actin are each d ...... d for Stereocilia maintenance.

@en

P1433

Q30990855-1B20E13E-DE01-4950-8C9A-59D5FA18AA81

P1476

Q30990855-63C25C47-2660-4B87-B6CE-A9B8A22A2CD1

P2093

Q30990855-90844A0B-D324-449F-AD64-4B1A2D93371B

Q30990855-9AEA149E-812D-4D94-8867-9FAED51195AE

Q30990855-B31F9379-F166-4342-9924-42ABAE413A5B

P2860

Q30990855-02A2B791-680A-46A7-AD5D-D4D5F39EE739

Q30990855-0688BD20-C08E-40AC-A81F-434042F63A0B

Q30990855-07524459-B317-4F0B-88BA-473A8BC786F3

Q30990855-10FB9FB8-41F5-4E50-AD62-4040A8AD5773

Q30990855-13950C85-F889-4660-B149-0AA54A94A875

Q30990855-17714B50-9ECE-478B-BD3F-EC6DF35B7834

Q30990855-2483FC64-D75D-4A43-95FE-187327A01983

Q30990855-24C1CCBE-946D-4078-85A7-E6BFFA4EEA8D

Q30990855-261DFB41-6FA8-45E6-8C89-B1AEA939F820

Q30990855-2D4588C4-A41A-4948-B3E3-029680110490

P304

Q30990855-EA00BEFB-0633-4875-9B2A-E0AD2FED6299

P31

Q30990855-EEB9684D-30E6-4337-A741-193AE7E731E3

P356

Q30990855-14ADA8E0-87F2-4DD9-ACD1-6E866244AEB4

P433

Q30990855-0A6A897B-073F-4978-AFFF-43ED88BD4EB3

P478

Q30990855-DC9827A3-4E89-4E43-B624-485B1261EF8E

P577

Q30990855-01B2CB88-0DE2-4E39-94CD-21577214F960

P5875

Q30990855-F10ECF47-95C9-4FB6-A06B-D8EE7AA35B9A

P698

Q30990855-F4CDE363-4663-4A16-8F12-131560EFD0BA

P932

Q30990855-3010F68F-2A22-4B6C-994B-998E3C28E2AD

P356

JOURNAL.PGEN.1001158

P1433

P1476

β-actin and γ-actin are each d ...... d for Stereocilia maintenance.

@en

P2093

Benjamin J Perrin

http://www.w3.org/2001/XMLSchema#string

James M Ervasti

http://www.w3.org/2001/XMLSchema#string

Kevin J Sonnemann

http://www.w3.org/2001/XMLSchema#string

P2860

A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia

A mutation in the gamma actin 1 (ACTG1) gene causes autosomal dominant hearing loss (DFNA20/26)

The functional importance of multiple actin isoforms

Cytoplasmic gamma-actin is not required for skeletal muscle development but its absence leads to a progressive myopathy

Beta cap73: a novel beta actin-specific binding protein

Age-related hearing loss and the ahl locus in mice

Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit

The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice

The dimensions and composition of stereociliary rootlets in mammalian cochlear hair cells: comparison between high- and low-frequency cells and evidence for a connection to the lateral membrane.

Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1.

P304

e1001158

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PGEN.1001158

http://www.w3.org/2001/XMLSchema#string

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P577

2010-10-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

47545583

http://www.w3.org/2001/XMLSchema#string

P698

20976199

http://www.w3.org/2001/XMLSchema#string

P932

2954897

http://www.w3.org/2001/XMLSchema#string