Reprogramming control of an allosteric signaling switch through modular recombination.
about
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASPMolecular mechanism of the Syk activation switchThe ankyrin repeat as molecular architecture for protein recognitionEnvironmental signal integration by a modular AND gateSynthetic biology: new engineering rules for an emerging disciplineAnalytics for Metabolic EngineeringRewiring cell signalling through chimaeric regulatory protein engineeringSynthetic analog and digital circuits for cellular computation and memoryElucidation of the binding preferences of peptide recognition modules: SH3 and PDZ domainsDesign principles underpinning the regulatory diversity of protein kinasesDesign of protein function leaps by directed domain interface evolutionChimeragenesis of distantly-related proteins by noncontiguous recombinationControl of protein signaling using a computationally designed GTPase/GEF orthogonal pairThe Designability of Protein Switches by Chemical Rescue of Structure: Mechanisms of Inactivation and ReactivationProgramming cells: towards an automated 'Genetic Compiler'Biology by design: reduction and synthesis of cellular components and behaviourHybrid and rogue kinases encoded in the genomes of model eukaryotes.Physical mechanisms of signal integration by WASP family proteins.Reengineering the signaling properties of a Src family kinase.Versatile retargeting of SH3 domain binding by modification of non-conserved loop residues.Activation of the Src family kinase Hck without SH3-linker release.Sequence-based prediction of protein domains.Generation of new protein functions by nonhomologous combinations and rearrangements of domains and modules.Directed evolution of protein switches and their application to the creation of ligand-binding proteins.HIV protease-activated molecular switches based on beta-glucuronidase and alkaline phosphatase.A specificity map for the PDZ domain familyLuciferase activity under direct ligand-dependent control of a muscarinic acetylcholine receptor.Large-scale evaluation of dynamically important residues in proteins predicted by the perturbation analysis of a coarse-grained elastic modelProligands with protease-regulated binding activity identified from cell-displayed prodomain librariesRapid diversification of cell signaling phenotypes by modular domain recombination.BglBricks: A flexible standard for biological part assemblyLogic integration of mRNA signals by an RNAi-based molecular computerSynthetic biology: applications come of ageTULIPs: tunable, light-controlled interacting protein tags for cell biology.Biology by design: from top to bottom and backKinetic buffering of cross talk between bacterial two-component sensors.Towards an artificial cell.PDZBase: a protein-protein interaction database for PDZ-domains.Linear motifs: evolutionary interaction switches.Reconstruction of genetic circuits.
P2860
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P2860
Reprogramming control of an allosteric signaling switch through modular recombination.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Reprogramming control of an allosteric signaling switch through modular recombination.
@ast
Reprogramming control of an allosteric signaling switch through modular recombination.
@en
type
label
Reprogramming control of an allosteric signaling switch through modular recombination.
@ast
Reprogramming control of an allosteric signaling switch through modular recombination.
@en
prefLabel
Reprogramming control of an allosteric signaling switch through modular recombination.
@ast
Reprogramming control of an allosteric signaling switch through modular recombination.
@en
P2093
P356
P1433
P1476
Reprogramming control of an allosteric signaling switch through modular recombination.
@en
P2093
Brian J Yeh
John E Dueber
Kayam Chak
Wendell A Lim
P304
P356
10.1126/SCIENCE.1085945
P407
P577
2003-09-01T00:00:00Z