Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
about
Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53The first 30 years of p53: growing ever more complexSmall-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyA panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53Jasmonates induce nonapoptotic death in high-resistance mutant p53-expressing B-lymphoma cellsCrucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisTreatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptideGlycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells.CP-31398, a putative p53-stabilizing molecule tested in mammalian cells and in yeast for its effects on p53 transcriptional activityCarcinogenesis and cancer prevention: the process and the disease deserve a better understandingProteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cellsChemical Variations on the p53 Reactivation ThemeOncogenic Intra-p53 Family Member Interactions in Human CancersTargeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer TherapyMutant p53: One, No One, and One Hundred ThousandTargeting Oncogenic Mutant p53 for Cancer TherapyCellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor RadiosensitizationNovel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promisingMyeloid malignancies: mutations, models and managementTumor suppressor p53 and its gain-of-function mutants in cancerResistance and gain-of-resistance phenotypes in cancers harboring wild-type p53Smoking, p53 mutation, and lung cancerP53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivationSmall molecule compounds targeting the p53 pathway: are we finally making progress?Inhibition of nutlin-resistant HDM2 mutants by stapled peptidesIdentification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agentsCrystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutationsStructures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescueThe rebel angel: mutant p53 as the driving oncogene in breast cancer.The p53 pathway as a target in cancer therapeutics: obstacles and promiseThe Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic TargetImmunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor MicroenvironmentThe role of p53 in cancer drug resistance and targeted chemotherapyEmerging Non-Canonical Functions and Regulation by p53: p53 and StemnessGenetically engineered mouse models in oncology research and cancer medicineGenomic profiling toward precision medicine in non-small cell lung cancer: getting beyond EGFRThe p53 circuit boardAPR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutationsActivation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70
P2860
Q24628577-19A43344-A534-4A9F-AECC-53576B12F1AAQ24645732-D9159EC7-0EF3-4105-B88E-F9C4E09E2F16Q24651380-390BCFF6-805A-424C-A875-811A1DFA1343Q24657532-D1D6FFFB-D6F3-4706-AC8C-06D34A3A235FQ24676240-BE5308EB-038D-4889-8D9C-2B7765B9D9FFQ24681977-F68FD65E-ED4A-4588-BFCA-7EEE9B1A199AQ24796110-71D954EB-7585-490B-96B3-3428F910848DQ24796572-07E75F71-E43D-43E8-80A3-EFD436A9503DQ24800091-7ACBA49F-E39B-4D5E-B5EB-E30C74485A42Q24801003-A93A0CD5-2D9D-44C1-BD52-9F076D1E86ECQ24813658-05A1B169-E341-475A-A6FF-C72E410BEDC5Q26749008-EC70E6E8-79FD-4D77-BFB0-1F70664E57CFQ26749382-0794FD11-D9F7-467C-86DC-3378888E66D3Q26766341-0121D361-7158-4D54-8213-C8C3901F4A7EQ26770576-C9077249-655D-4E59-B3C5-833E892E65DDQ26770856-206B68B4-30D1-4B49-9A90-15E93BB8E116Q26771165-D14712B9-077C-4D24-ADF3-B420F3AA298EQ26777988-DED262FE-B677-4856-B0F0-EE54F3913EE4Q26863501-CE606A60-7337-4FCD-8B7C-B9FC7021E528Q27000577-6589F815-F97D-448B-97FD-CE9A0B8CF3F4Q27000754-BF0C9B2E-56F0-4022-8C63-D7D5BD86E0BEQ27006998-42839E01-A716-405A-8E44-4AD1065E02D9Q27014977-457E5799-DE01-4910-874D-8854C9750AD9Q27021759-A927F5FD-3B4F-4BC5-96E1-8B69AE9CCEE3Q27027835-380138B6-18E2-445F-A6F7-A8113B3CCE6BQ27301404-0C998B25-15AB-41A9-998A-0008EEED2F8BQ27318801-48969737-28BB-47F5-ACFB-AB7A4FCC1DF8Q27642314-F291D6A3-FDCF-4C95-B546-217BAE962068Q27680171-9A591C6B-925E-44A9-8039-7DE9944F2A45Q27686765-222A49ED-BD62-43F0-91E0-04A8ABDD8E37Q27690770-399D9F8C-EE0B-47F5-9A2A-28E4DE98D564Q28071415-6BA64C7A-8601-4B8F-A73E-B57F97C5B41EQ28071935-DE34FDEA-A19D-44DE-8F61-C95655449477Q28072553-35DA2FBB-6F32-4047-8027-A579496590D3Q28077156-8C3F832C-6137-4A41-9B0C-785642B474B8Q28079323-5ED23C81-B23F-4F17-986B-7D1D09C63A7BQ28086993-A5729B0B-0CE1-423B-88F2-54857FA44F52Q28259725-4C0215A3-5616-498D-B70F-F861481A3766Q28284341-960AA1FB-0AC7-47AF-9381-2F45BF2C5E71Q28472376-AE589461-BF8A-4B6B-8408-AA7242E5CC7F
P2860
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Restoration of the tumor suppr ...... low-molecular-weight compound.
@ast
Restoration of the tumor suppr ...... low-molecular-weight compound.
@en
type
label
Restoration of the tumor suppr ...... low-molecular-weight compound.
@ast
Restoration of the tumor suppr ...... low-molecular-weight compound.
@en
prefLabel
Restoration of the tumor suppr ...... low-molecular-weight compound.
@ast
Restoration of the tumor suppr ...... low-molecular-weight compound.
@en
P2093
P50
P356
P1433
P1476
Restoration of the tumor suppr ...... low-molecular-weight compound
@en
P2093
Alexandre Shilov
Jan Bergman
Monica Hultcrantz
Natalia Issaeva
Vladimir J N Bykov
P2888
P304
P356
10.1038/NM0302-282
P407
P577
2002-03-01T00:00:00Z
P5875
P6179
1049307674