The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production. - Wikidata - awgldk - TriplyDB

The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production.

The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production.

http://www.wikidata.org/entity/Q31057510

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Schnitzler's syndrome: lessons from 281 cases The Pathogenesis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: A Review of Current Research NOD-Like Receptors: Master Regulators of Inflammation and Cancer Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns Phenotypic and genotypic characteristics of cryopyrin-associated periodic syndrome: a series of 136 patients from the Eurofever Registry.C10X polymorphism in the CARD8 gene is associated with bacteraemia.Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome.A balanced IL-1β activity is required for host response to Citrobacter rodentium infection.Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.Clinical features and genetic background of the periodic Fever syndrome with aphthous stomatitis, pharyngitis, and adenitis: a single center longitudinal study of 81 patients Genetic profiling of autoinflammatory disorders in patients with periodic fever: a prospective study.NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis.Protein-bound polysaccharide-K induces IL-1β via TLR2 and NLRP3 inflammasome activation.Expanding spectrum of neurologic manifestations in patients with NLRP3 low-penetrance mutations.Analysis of the genetic basis of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome.Acquired familial Mediterranean fever associated with a somatic MEFV mutation in a patient with JAK2 associated post-polycythemia myelofibrosis.NLRP3 Inflammasome Polymorphism and Macrovascular Complications in Type 2 Diabetes Patients Association of pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) shares genetic and cytokine profiles with other autoinflammatory diseases.Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout.The Q705K and F359L Single-Nucleotide Polymorphisms of NOD-Like Receptor Signaling Pathway: Association with Chronic Pancreatitis, Pancreatic Cancer, and Periodontitis.NLRP3 p.Q705K and CARD8 p.C10X single nucleotide polymorphisms are not associated with susceptibility to rheumatoid arthritis: a meta-analysis.Arginine Relieves the Inflammatory Response and Enhances the Casein Expression in Bovine Mammary Epithelial Cells Induced by Lipopolysaccharide Association of a variable number tandem repeat in the NLRP3 gene in women with susceptibility to RVVC Clinical characteristics in subjects with NLRP3 V198M diagnosed at a single UK center and a review of the literature.Danger signalling during cancer cell death: origins, plasticity and regulation.Genes involved in innate immunity associated with asbestos-related fibrotic changes Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals.Human gene variants linked to enhanced NLRP3 activity limit intramacrophage growth of Mycobacterium tuberculosis.Activation of toll-like receptors and inflammasome complexes in the diabetic cardiomyopathy-associated inflammation.NLRP3 and CARD8 Polymorphisms Influence Higher Disease Activity in Rheumatoid Arthritis.Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond.Targeting inflammasomes in rheumatic diseases.Association of NLRP3 and CARD8 genetic polymorphisms with juvenile idiopathic arthritis in a Taiwanese population.Diagnosis of cryopyrin-associated periodic syndrome: challenges, recommendations and emerging concepts.Trained immunity: a new avenue for tuberculosis vaccine development.Autoinflammatory diseases: update on classification diagnosis and management.Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction.Clinical and molecular phenotypes of low-penetrance variants in NLRP3: Diagnostic and therapeutic challenges.Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome.

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P2860

The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production.

http://www.wikidata.org/entity/Q31057510

description

2012 nî lūn-bûn

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2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2012 թվականի ապրիլին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

The Q705K polymorphism in NLRP ...... eukin-1β and IL-18 production.

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The Q705K polymorphism in NLRP ...... eukin-1β and IL-18 production.

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type

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The Q705K polymorphism in NLRP ...... eukin-1β and IL-18 production.

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The Q705K polymorphism in NLRP ...... eukin-1β and IL-18 production.

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The Q705K polymorphism in NLRP ...... eukin-1β and IL-18 production.

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The Q705K polymorphism in NLRP ...... eukin-1β and IL-18 production.

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The Q705K polymorphism in NLRP ...... eukin-1β and IL-18 production.

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Deepti Verma

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Eva Särndahl

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Henrik Andersson

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Maria Lerm

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Mats Fredrikson

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P2860

Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling

ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis

Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways

The inflammasomes

Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

The tumour necrosis factor receptor-associated periodic syndrome: current concepts

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

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Jan-Ingvar Jönsson

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