Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.

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http://www.wikidata.org/entity/Q31122876
There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative DiseasesSmall GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating AutophagyPhosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.Targeting TDP-43 in neurodegenerative diseases.Nucleoli and stress granules: connecting distant relatives.Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue.TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.TDP-43 expression influences amyloidβ plaque deposition and tau aggregation.ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2.Malonate induces the assembly of cytoplasmic stress granules.The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
P2860

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.

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http://www.wikidata.org/entity/Q31122876
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2013 nî lūn-bûn
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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Kinase Inhibitor Screening Ide ...... cumulation during Cell Stress.
@ast
Kinase Inhibitor Screening Ide ...... cumulation during Cell Stress.
@en
type
label
Kinase Inhibitor Screening Ide ...... cumulation during Cell Stress.
@ast
Kinase Inhibitor Screening Ide ...... cumulation during Cell Stress.
@en
prefLabel
Kinase Inhibitor Screening Ide ...... cumulation during Cell Stress.
@ast
Kinase Inhibitor Screening Ide ...... cumulation during Cell Stress.
@en
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Kinase Inhibitor Screening Ide ...... cumulation during Cell Stress.
@en
P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0067433
P407
P433
P478
P50
P577
P5875
P698
P932