A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells.
about
Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channelsThe mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in ratsHigh throughput screening technologies for ion channelsThe Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neuronsPotent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1.High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1.Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1.Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities.Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels.A novel mitochondrial K(ATP) channel assay.Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.Analysis of plasma membrane integrity by fluorescent detection of Tl(+) uptake.SLO-2 is cytoprotective and contributes to mitochondrial potassium transport.Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactionsNS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiasIdentification of novel small molecule modulators of K2P18.1 two-pore potassium channel.High-throughput screening for small-molecule modulators of inward rectifier potassium channels.High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells.G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells.A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.Cloning and functional characterization of inward-rectifying potassium (Kir) channels from Malpighian tubules of the mosquito Aedes aegyptiVoltage-gated potassium channels as therapeutic targets.Direct control of Na(+)-K(+)-2Cl(-)-cotransport protein (NKCC1) expression with aldosteroneOptical control of neuronal activity using a light-operated GIRK channel opener (LOGO).Screening technologies for ion channel drug discovery.Natural and artificial ion channels for biosensing platforms.Advances in functional assays for high-throughput screening of ion channels targets.Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.Predicting drug-induced QT prolongation and torsades de pointes: a review of preclinical endpoint measures.Targeting cardiac potassium channels for state-of-the-art drug discovery.Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel.Functional Studies of Sodium Channels: From Target to Compound Identification.
P2860
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P2860
A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells.
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A thallium-sensitive, fluoresc ...... modulators in mammalian cells.
@ast
A thallium-sensitive, fluoresc ...... modulators in mammalian cells.
@en
type
label
A thallium-sensitive, fluoresc ...... modulators in mammalian cells.
@ast
A thallium-sensitive, fluoresc ...... modulators in mammalian cells.
@en
prefLabel
A thallium-sensitive, fluoresc ...... modulators in mammalian cells.
@ast
A thallium-sensitive, fluoresc ...... modulators in mammalian cells.
@en
P2093
P2860
P356
P1476
A thallium-sensitive, fluoresc ...... modulators in mammalian cells.
@en
P2093
Barbara Robertson
C David Weaver
David Harden
Ronald J Knox
Steven I Dworetzky
P2860
P304
P356
10.1177/1087057104268749
P577
2004-12-01T00:00:00Z