New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products.
about
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4Hot spots in prion protein for pathogenic conversionDiscovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cellsAnti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approachesSynergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruziMethotrexate Is a JAK/STAT Pathway InhibitorA novel way to grow hemozoin-like crystals in vitro and its use to screen for hemozoin inhibiting antimalarial compoundsStyryl-based and tricyclic compounds as potential anti-prion agentsKinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effectsEffects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning.Variety of antiprion compounds discovered through an in silico screen based on cellular-form prion protein structure: Correlation between antiprion activity and binding affinity.Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins.Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets.A synergistic small-molecule combination directly eradicates diverse prion strain structuresFrom high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.Preclinical studies of celastrol and acetyl isogambogic acid in melanoma.Discovery of 2-aminothiazoles as potent antiprion compounds.Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agentsManipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9.Successes and challenges in phenotype-based lead discovery for prion diseasesInhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting diseaseMefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivoCharacterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones.Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.Cellular and molecular actions of Methylene Blue in the nervous systemMouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res.Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides.Spironolactone blocks Epstein-Barr virus production by inhibiting EBV SM protein function.Screening and identification of compounds with antiviral activity against hepatitis B virus using a safe compound library and novel real-time immune-absorbance PCR-based high throughput system.The most infectious prion protein particles.Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitorsAntiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.Enhanced antiscrapie effect using combination drug treatmentA survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa.Protein folding activity of the ribosome (PFAR) -- a target for antiprion compoundsGeneration of a persistently infected MDBK cell line with natural bovine spongiform encephalopathy (BSE).Reaction of complement factors varies with prion strains in vitro and in vivo.Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells.
P2860
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P2860
New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products.
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
name
New inhibitors of scrapie-asso ...... 00 drugs and natural products.
@ast
New inhibitors of scrapie-asso ...... 00 drugs and natural products.
@en
type
label
New inhibitors of scrapie-asso ...... 00 drugs and natural products.
@ast
New inhibitors of scrapie-asso ...... 00 drugs and natural products.
@en
prefLabel
New inhibitors of scrapie-asso ...... 00 drugs and natural products.
@ast
New inhibitors of scrapie-asso ...... 00 drugs and natural products.
@en
P2093
P2860
P1433
P1476
New inhibitors of scrapie-asso ...... 00 drugs and natural products.
@en
P2093
David A Kocisko
Gerald S Baron
Jiancao Chen
Richard Rubenstein
Salomon Kuizon
P2860
P304
10288-10294
P356
10.1128/JVI.77.19.10288-10294.2003
P577
2003-10-01T00:00:00Z