Discovery of 2-aminothiazoles as potent antiprion compounds. - Wikidata - awgldk - TriplyDB

Discovery of 2-aminothiazoles as potent antiprion compounds.

Discovery of 2-aminothiazoles as potent antiprion compounds.

http://www.wikidata.org/entity/Q33520644

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2-Aminothiazoles as therapeutic leads for prion diseases Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents Successes and challenges in phenotype-based lead discovery for prion diseases Prion protein-specific antibodies-development, modes of action and therapeutics application Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.Palladium-catalyzed N-arylation of 2-aminothiazoles Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.Inhibition of PrP(Sc) formation in scrapie infected N2a cells by 5,7,8-trimethyl-3,4-dihydro-2H-1,4-benzoxazine derivatives.Characterization of 8-hydroxyquinoline derivatives containing aminobenzothiazole as inhibitors of dengue virus type 2 protease in vitro Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.Discovery and Preliminary SAR of Arylpiperazines as Novel, Brainpenetrant Antiprion Compounds.Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein 4-Bromo-2-[5-methyl-2-(morpholin-4-yl)-1,3-thia-zol-4-yl]phenol.Drug resistance confounding prion therapeutics.2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease Quinacrine promotes replication and conformational mutation of chronic wasting disease prions.Emergence and natural selection of drug-resistant prions.Insights from Therapeutic Studies for PrP Prion Disease.Developing Therapeutics for PrP Prion Diseases.Exploring Anti-Prion Glyco-Based and Aromatic Scaffolds: A Chemical Strategy for the Quality of Life.Implications of peptide assemblies in amyloid diseases.Establishment of a simple cell-based ELISA for the direct detection of abnormal isoform of prion protein from prion-infected cells without cell lysis and proteinase K treatment.Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles.Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds Discovery of small molecules binding to the normal conformation of prion by combining virtual screening and multiple biological activity evaluation methods.Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents.Biology and Genetics of PrP Prion Strains.4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents Novel Thiazole Derivatives of Medicinal Potential: Synthesis and Modeling

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Discovery of 2-aminothiazoles as potent antiprion compounds.

http://www.wikidata.org/entity/Q33520644

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Discovery of 2-aminothiazoles as potent antiprion compounds.

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Discovery of 2-aminothiazoles as potent antiprion compounds.

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Discovery of 2-aminothiazoles as potent antiprion compounds.

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type

label

Discovery of 2-aminothiazoles as potent antiprion compounds.

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Discovery of 2-aminothiazoles as potent antiprion compounds.

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Discovery of 2-aminothiazoles as potent antiprion compounds.

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Discovery of 2-aminothiazoles as potent antiprion compounds.

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Discovery of 2-aminothiazoles as potent antiprion compounds.

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Discovery of 2-aminothiazoles as potent antiprion compounds.

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Journal of Virology

P1476

Discovery of 2-aminothiazoles as potent antiprion compounds.

@en

P2093

Barnaby C H May

http://www.w3.org/2001/XMLSchema#string

Sina Ghaemmaghami

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P2860

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

Shattuck lecture--neurodegenerative diseases and prions

New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products.

JColorGrid: software for the visualization of biological measurements.

Library synthesis and screening: 2,4-diphenylthiazoles and 2,4-diphenyloxazoles as potential novel prion disease therapeutics.

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

Molecular biology of prion diseases.

2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (d

Quinoline derivatives are therapeutic candidates for transmissible spongiform encephalopathies.

Cell division modulates prion accumulation in cultured cells

P304

3408-3412

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scholarly article

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10.1128/JVI.02145-09

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7

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84

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Stanley B. Prusiner

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2009-12-23T00:00:00Z

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40767682

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20032192

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2838138

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