Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.
about
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteinsModulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase CdeltaPhosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activityS6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase CzetaInsulin receptor signaling in normal and insulin-resistant statesNovel applications of COX-2 inhibitors, metformin, and statins for the primary chemoprevention of breast cancerRegulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2A dynamic analysis of IRS-PKR signaling in liver cells: a discrete modeling approach.Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to inIdentification of an in vitro insulin receptor substrate-1 phosphorylation site by negative-ion muLC/ES-API-CID-MS hybrid scan technique.The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cellsIntracellular signalling mechanisms regulating glucose transport in insulin-sensitive tissues (review).TNF ligands and receptors--a matter of life and death.Novel insulin sensitizers: pharmacogenomic aspects.Computational modelling of the regulation of Insulin signalling by oxidative stress.PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction.Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytesAdvanced glycation end products and oxidative stress in type 2 diabetes mellitus.Causal drift, robust signaling, and complex disease.Morphine induces desensitization of insulin receptor signaling.Metformin: multi-faceted protection against cancer.Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism.Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistanceEffect of SNPs in protein kinase C zeta gene on gene expression in the reporter gene detection systemIgf2 ligand dependency of Pten(+/-) developmental and tumour phenotypes in the mouseTurning down insulin signaling.Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.Protein kinase C/zeta (PRKCZ) gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes.Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid EmulsionProtein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.Uteroplacental insufficiency down regulates insulin receptor and affects expression of key enzymes of long-chain fatty acid (LCFA) metabolism in skeletal muscle at birthProtein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes.Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscleCoenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth.Protein Scaffolds Control Localized Protein Kinase Cζ Activity.In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.Phosphorylation of IRS proteins, insulin action, and insulin resistance.
P2860
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P2860
Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Protein kinase C-zeta phosphor ...... kinase in response to insulin.
@ast
Protein kinase C-zeta phosphor ...... kinase in response to insulin.
@en
type
label
Protein kinase C-zeta phosphor ...... kinase in response to insulin.
@ast
Protein kinase C-zeta phosphor ...... kinase in response to insulin.
@en
prefLabel
Protein kinase C-zeta phosphor ...... kinase in response to insulin.
@ast
Protein kinase C-zeta phosphor ...... kinase in response to insulin.
@en
P2093
P356
P1476
Protein kinase C-zeta phosphor ...... -kinase in response to insulin
@en
P2093
D L Esposito
L V Ravichandran
P304
P356
10.1074/JBC.M007231200
P407
P577
2000-11-03T00:00:00Z