A functional DNA binding domain is required for growth hormone-induced nuclear accumulation of Stat5B.
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The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperonePrinciples of interleukin (IL)-6-type cytokine signalling and its regulationDifferential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbetaAutophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activityCytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulationActivation-induced nuclear translocation of RING3A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocationInteraction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activationThe angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.Real time analysis of STAT3 nucleocytoplasmic shuttling.Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alphaSH2-B family members differentially regulate JAK family tyrosine kinases.Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity.Two glutamic acid residues in the DNA-binding domain are engaged in the release of STAT1 dimers from DNA.Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor.DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1.Mutations that reduce its specific DNA binding inhibit high NaCl-induced nuclear localization of the osmoprotective transcription factor NFAT5Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.Tracking STAT nuclear traffic.Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding protein.Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system.Functional relevance of the conserved DNA-binding domain of STAT2.Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways.The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation.Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways.A rapid conformational rearrangement of STAT1 dimers is required for termination rather than for amplification of interferon-γ signaling.Skin fibroblasts of children with idiopathic short stature show an increased mitogenic response to IGF-I and secrete more IGFBP-3.Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells.Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO).SH2-B is required for growth hormone-induced actin reorganization.
P2860
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P2860
A functional DNA binding domain is required for growth hormone-induced nuclear accumulation of Stat5B.
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A functional DNA binding domai ...... uclear accumulation of Stat5B.
@ast
A functional DNA binding domai ...... uclear accumulation of Stat5B.
@en
type
label
A functional DNA binding domai ...... uclear accumulation of Stat5B.
@ast
A functional DNA binding domai ...... uclear accumulation of Stat5B.
@en
prefLabel
A functional DNA binding domai ...... uclear accumulation of Stat5B.
@ast
A functional DNA binding domai ...... uclear accumulation of Stat5B.
@en
P2093
P356
P1476
A functional DNA binding domai ...... uclear accumulation of Stat5B.
@en
P2093
P304
P356
10.1074/JBC.274.8.5138
P407
P577
1999-02-01T00:00:00Z